Cancer cell metabolism and antitumour immunity
De Martino M, Rathmell J, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nature Reviews Immunology 2024, 1-16. PMID: 38649722, DOI: 10.1038/s41577-024-01026-4.Peer-Reviewed Original ResearchCell-extrinsic mechanismsCancer cell-extrinsic mechanismsCancer cell-intrinsicAntitumour immune responseAdverse microenvironmental conditionsIncreased proliferative potentialAccelerated disease progressionAdaptive immune functionMetabolic rewiringAnticancer immunityMalignant cellsAlteration of metabolismTumor progressionCell-intrinsicMicroenvironmental conditionsDisease progressionProliferative potentialImmune responseCancer cellsImmune functionTherapeutic purposesCancerAlterationsCellsTumorLive Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids.
Charpentier M, Bloy N, Formenti S, Galluzzi L, Demaria S. Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids. Journal Of Visualized Experiments 2024 PMID: 38647326, DOI: 10.3791/66680.Peer-Reviewed Original ResearchConceptsPatient-derived tumor organoidsClonogenic assayRadiation therapyTumor organoidsCancer cellsIrradiated cancer cellsMeasure of radiosensitivityClinical cancer managementNon-irradiated (controlDose-dependent mannerSingle-cell suspensionsMalignant cellsTumor modelCancer managementCellular radiosensitivitySensitive to irradiationComplex tumor modelsOxidative DNA damageRepair oxidative DNA damageCancer typesDelayed mannerIonizing raysSingle-cell dissociationFlow cytometry-RadiosensitivityImmunogenicity of ferroptosis in cancer: a matter of context?
Catanzaro E, Demuynck R, Naessens F, Galluzzi L, Krysko D. Immunogenicity of ferroptosis in cancer: a matter of context? Trends In Cancer 2024, 10: 407-416. PMID: 38368244, DOI: 10.1016/j.trecan.2024.01.013.Peer-Reviewed Original ResearchTumor-targeting immune responsesImmune responseCancer cellsKill malignant cellsAdaptive immune responsesInduction of ferroptosisImmunogenicity of ferroptosisAnticancer immunityMicroenvironmental defectMalignant cellsImmune cellsPlasma membrane breakdownFerroptosis inducersNecrotic formCell deathFerroptosisImbalance of cellular redox homeostasisLipid peroxidationCellsMembrane breakdownCellular redox homeostasisRedox homeostasisContext-dependent effectsImmunogenicityAdjuvanticityGeneration of transmitochondrial cybrids in cancer cells
Soler-Agesta R, Ripollés-Yuba C, Marco-Brualla J, Moreno-Loshuertos R, Sato A, Beltrán-Visiedo M, Galluzzi L, Anel A. Generation of transmitochondrial cybrids in cancer cells. Methods In Cell Biology 2024 DOI: 10.1016/bs.mcb.2024.05.010.Peer-Reviewed Original ResearchTransmitochondrial cybridsCancer cellsApoptotic cell deathSource of ATPCancer cell functionsMitochondrial genomeCircular genomeNuclear genesMitochondrial DNATransfer RNAMitochondrial proteinsRibosomal RNAMitochondrial componentsIntact mitochondriaMitochondrial functionCybridsCell deathMetabolic intermediatesMitochondriaGenomeCell functionRNACellsTumor progressionAbundant sourceCytofluorometric assessment of calreticulin exposure on CD38+ plasma cells from the human bone marrow
Beltrán-Visiedo M, Valle A, Jiménez-Aldúan N, Soler-Agesta R, Naval J, Galluzzi L, Marzo I. Cytofluorometric assessment of calreticulin exposure on CD38+ plasma cells from the human bone marrow. Methods In Cell Biology 2024 DOI: 10.1016/bs.mcb.2024.05.009.Peer-Reviewed Original ResearchCD38+ plasma cellsMultiple myelomaDendritic cellsBone marrowPlasma cellsProfessional antigen-presenting cellsBone marrow of patientsAssociated with improved disease outcomeMarrow of patientsAntigen-presenting cellsSurface of malignant cellsSurface of cancer cellsDying cellsAdaptive immune responsesChaperone calreticulinHuman bone marrowCalreticulin exposureEffector phaseMalignant cellsTolerogenic macrophagesExposure of phosphatidylserineImmunological memoryImmune responseClinical relevanceCancer cells