2025
Reframing the paradigm- rethinking placental and fetal immunity
Konnikova L. Reframing the paradigm- rethinking placental and fetal immunity. Placenta 2025 PMID: 40425428, DOI: 10.1016/j.placenta.2025.05.011.Peer-Reviewed Original ResearchPreterm birthMemory T cellsFetal immunityPreterm laborT cellsImmune cellsImmune developmentImmune systemNeonatal immune cellsReducing preterm laborFetal immune systemFetal immune developmentWeeks of gestationFetal immune responseMaternal tolerancePlacental immunityFetal organsCord bloodImmune environmentInfant bloodNeonatal healthImmunological issuesNeonatal protectionPrevent complicationsImmune responseSpatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation
Velagala S, Phan L, Eke C, Fernandes A, Rice T, Olaloye O, Konnikova L. Spatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation. Mucosal Immunology 2025 PMID: 40288579, DOI: 10.1016/j.mucimm.2025.04.005.Peer-Reviewed Original ResearchVascular smooth muscle cellsPlacental villiSmooth muscle cellsMid-gestationMyeloid-derived suppressor cellsMuscle cellsMechanisms of preterm birthMaternal immune systemInnate lymphoid cellsRare T cellsFull-term samplesTolerogenic statePreterm birthSuppressor cellsImmune remodelingPregnancy complicationsDendritic cellsActivation markersT cellsImaging mass cytometryLymphoid cellsImmune populationsMacrophage subtypesSyncytial trophoblastImmune system
2024
Placenta and Intestinal Injury in Preterm Infants
Garg P, Weitkamp J, McDonald A, Cilvik S, Mir I, Shenberger J, Olaloye O, Konnikova L, Kallapur S, Garg P. Placenta and Intestinal Injury in Preterm Infants. American Journal Of Perinatology 2024, 42: 415-419. PMID: 38889889, PMCID: PMC11724007, DOI: 10.1055/a-2347-4135.Peer-Reviewed Original ResearchNecrotizing enterocolitisIntestinal injuryRisk factors associated with necrotizing enterocolitisDevelopment of necrotizing enterocolitisLow birth weight infantsAssociated with intestinal injuryExposure to inflammationProspective multi-center studyAt-risk infantsHuman clinical studiesMulti-center studyPreterm infantsPlacental pathologyPreterm birthImmunomodulatory treatmentIntrauterine environmentLaboratory predictorsCause of deathClinical outcomesClinical impactClinical studiesPostnatal lifeVulnerable infantsPost pregnancyTriggering inflammation
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