2025
Renalase levels are decreased in maternal blood and placental tissues in pregnancies associated with preterm preeclampsia
Soliman Y, Eke C, Guo X, Wang M, Silva T, Désir G, Konnikova L. Renalase levels are decreased in maternal blood and placental tissues in pregnancies associated with preterm preeclampsia. Scientific Reports 2025, 15: 6480. PMID: 39987333, PMCID: PMC11846959, DOI: 10.1038/s41598-025-90524-z.Peer-Reviewed Original ResearchConceptsCases of preeclampsiaSerum renalasePreterm casesRenalase levelsPregnancies associated with hypertensionFactors associated with preeclampsiaRisk of eclampsiaPathophysiology of preeclampsiaLevels of renalasePreterm preeclampsiaTerm preeclampsiaMaternal serumMaternal bloodRenalase expressionPlacental villiPreeclampsiaPlacental tissuePretermPlacentaRenalaseMaternal healthPregnancyHypertensionSerumVariable effects
2022
Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation
Wang M, Silva T, Toothaker JM, McCourt BT, Shugrue C, Desir G, Gorelick F, Konnikova L. Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation. Scientific Reports 2022, 12: 4953. PMID: 35322081, PMCID: PMC8943056, DOI: 10.1038/s41598-022-08817-6.Peer-Reviewed Original ResearchConceptsPlacental tissuePlacental villiHofbauer cellsPlacental developmentEndogenous productionAnti-inflammatory milieuPotential roleHuman placental tissueFull-term placentaPlacental factorsFetal interfaceDecidual samplesPlacental functionChorionic plateImmunoreactive cellsPlacental samplesHuman gestationRenalaseBulk RNA sequencingHuman placentaPlacentaQuantification of immunohistochemistryProtein levelsTrophoblastTransmission of nutrients
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