2025
A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants
Olaloye O, Gu W, Gehlhaar A, Sabuwala B, Eke C, Li Y, Kehoe T, Farmer R, Gabernet G, Lucas C, Tsang J, Lakhani S, Taylor S, Tseng G, Kleinstein S, Konnikova L. A single-cell atlas of circulating immune cells over the first 2 months of age in extremely premature infants. Science Translational Medicine 2025, 17: eadr0942. PMID: 40043141, DOI: 10.1126/scitranslmed.adr0942.Peer-Reviewed Original ResearchConceptsExtremely premature infantsFull-term infantsT cellsMonths of lifePremature infantsImmune cellsMemory CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cellsMemory-like T cellsAnalysis of immune cellsNaive CD4<sup>+</sup>Peripheral T cell developmentWeeks of gestationCord blood samplesNatural killer cellsT helper 1B cell receptor sequencesT cell developmentCycling T cellsMonths of ageSingle-cell suspensionsAmount of bloodSusceptibility to infectionCD4<sup>+</sup>Killer cells
2024
Enhanced placental antibody transfer efficiency with longer interval between maternal RSV vaccination and birth
Jasset O, Lopez Zapana P, Bahadir Z, Shook L, Dennis M, Gilbert E, Liu Z, Yinger R, Bald C, Bradford C, Silfen A, Klein S, Pekosz A, Permar S, Konnikova L, Yonker L, Lauffenburger D, Nelson A, Elovitz M, Edlow A. Enhanced placental antibody transfer efficiency with longer interval between maternal RSV vaccination and birth. American Journal Of Obstetrics And Gynecology 2024 PMID: 39515450, DOI: 10.1016/j.ajog.2024.10.053.Peer-Reviewed Original ResearchMaternal RSV vaccineRespiratory syncytial virusRespiratory syncytial virus vaccineNatural RSV infectionRSV vaccineRSV infectionBinding antibody multiplex assayTiming of maternal vaccinationTransplacental transfer of maternal antibodiesAntibody levelsRespiratory syncytial virus strains A2Vaccine administrationInfant antibody levelsMaternal antibodiesMother to fetusProspective cohort studyTransfer of maternal antibodiesWilcoxon rank sum testWeek windowVaccination timingLevels of IgGRank sum testTransfer of antibodiesMonths of ageGestational age
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