2025
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice
Li J, Jacobse J, Pilat J, Kaur H, Gu W, Kang S, Rusznak M, Huang H, Barrera J, Oloo P, Roland J, Hawkins C, Pahnke A, Khalil M, Washington M, Wilson K, Williams C, Peebles R, Konnikova L, Choksi Y, Hammer G, Lau K, Goettel J. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunology 2025 PMID: 39988202, DOI: 10.1016/j.mucimm.2025.02.005.Peer-Reviewed Original ResearchInnate lymphoid cellsIL-10Lymphoid cellsImmune homeostasisInterleukin-10Population of innate lymphoid cellsIntestinal inflammationIntestinal macrophagesIL-10 receptor signalingModel of experimental colitisPromote immune homeostasisInterleukin-10 productionFluorescent protein reporterIL-10 productionIntestinal immune homeostasisCX3CR1-expressing cellsRNA in situ hybridizationCell-specific targetingAdoptive transferSpontaneous colitisProtein reporterIL10 deficiencyReporter miceImmune cellsImmunomodulatory cytokines
2020
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, Center B, Ballal S, Bonilla S, Fawaz R, Fishman L, Flores A, Fox V, Grover A, Higuchi L, Huh S, Kahn S, Lee C, Mobassaleh M, Ouahed J, Pleskow R, Regan B, Rufo P, Sabharwal S, Silverstein J, Verhave M, Wolf A, Zimmerman L, Zitomersky N, Center B, Allegretti J, De Silva P, Friedman S, Hamilton M, Korzenik J, Makrauer F, Norton B, Winter R, Shalek A, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper S, Konnikova L. Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease. Gastroenterology 2020, 159: 591-608.e10. PMID: 32428507, PMCID: PMC8166295, DOI: 10.1053/j.gastro.2020.04.074.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseasePeripheral blood mononuclear cellsActive Crohn's diseaseBlood mononuclear cellsColonic mucosa samplesActive ulcerative colitisPlasmacytoid dendritic cellsInnate lymphoid cellsUlcerative colitisCrohn's diseaseDendritic cellsImmune cell populationsRegulatory cellsMononuclear cellsT cellsMucosa samplesBlood samplesLymphoid cellsGroup 1 innate lymphoid cellsType 3 innate lymphoid cellsEffector memory T cellsCell populationsInactive ulcerative colitisInactive Crohn's diseaseMemory T cells
2019
Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development
Stras SF, Werner L, Toothaker JM, Olaloye OO, Oldham AL, McCourt CC, Lee YN, Rechavi E, Shouval DS, Konnikova L. Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development. Developmental Cell 2019, 51: 357-373.e5. PMID: 31607651, DOI: 10.1016/j.devcel.2019.09.008.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesCell ProliferationClone CellsCytokinesFemaleFetal DevelopmentFetusHumansImmune SystemImmunity, MucosalImmunologic MemoryImmunophenotypingInfant, NewbornIntestinesPregnancyPregnancy Trimester, SecondReceptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesV(D)J RecombinationConceptsInnate lymphoid cellsGestational ageIntestinal immunityDendritic cellsB cellsHuman intestinal immune systemAdaptive immune landscapeIntestinal immune systemNatural killer cellsWeeks gestational ageTransitional B cellsB cell maturityT cell receptorComplex innateImmune atlasEarly life developmentImmune landscapeKiller cellsTCR repertoireLymphoid cellsFetal developmentImmune systemInnate immunityCell receptorMass cytometryHigh-dimensional immune atlas of second trimester human intestinal immunity
Konnikova L, Stras S, Werner L, Toothaker J, Oldham A, Shouval D. High-dimensional immune atlas of second trimester human intestinal immunity. The Journal Of Immunology 2019, 202: 67.12-67.12. DOI: 10.4049/jimmunol.202.supp.67.12.Peer-Reviewed Original ResearchT cellsImmune atlasIntestinal immunityB cellsImmune systemTissue-resident memory T cellsLarge intestineResident memory T cellsMucosal immune developmentNeonatal immune systemEffector memory subsetsInnate lymphoid cellsMemory T cellsNatural killer cellsTransitional B cellsT cell receptorFull-term samplesMost newbornsWeeks' gestationAdvanced gestationKiller cellsMucosal immunityNeonatal deathMemory subsetsImmune cells
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