2025
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice
Li J, Jacobse J, Pilat J, Kaur H, Gu W, Kang S, Rusznak M, Huang H, Barrera J, Oloo P, Roland J, Hawkins C, Pahnke A, Khalil M, Washington M, Wilson K, Williams C, Peebles R, Konnikova L, Choksi Y, Hammer G, Lau K, Goettel J. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunology 2025 PMID: 39988202, DOI: 10.1016/j.mucimm.2025.02.005.Peer-Reviewed Original ResearchInnate lymphoid cellsIL-10Lymphoid cellsImmune homeostasisInterleukin-10Population of innate lymphoid cellsIntestinal inflammationIntestinal macrophagesIL-10 receptor signalingModel of experimental colitisPromote immune homeostasisInterleukin-10 productionFluorescent protein reporterIL-10 productionIntestinal immune homeostasisCX3CR1-expressing cellsRNA in situ hybridizationCell-specific targetingAdoptive transferSpontaneous colitisProtein reporterIL10 deficiencyReporter miceImmune cellsImmunomodulatory cytokines
2022
Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation
Gehlhaar A, Inala A, Llivichuzhca-Loja D, Silva TN, Adegboye CY, O’Connell A, Konnikova L. Insights into the Role of Commensal-Specific T Cells in Intestinal Inflammation. Journal Of Inflammation Research 2022, 15: 1873-1887. PMID: 35342295, PMCID: PMC8943607, DOI: 10.2147/jir.s288288.Peer-Reviewed Original ResearchT cellsIntestinal inflammationIntestinal inflammatory responseDamaging autoimmune responsesTrillions of microorganismsImmunological balanceAutoimmune responseImmune homeostasisInflammatory responseImmune systemMucosal interfaceBarrier sitesHuman intestineInflammationIntestinePrevious evidenceCellsCD8CD4ThymusResponse
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