2025
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice
Li J, Jacobse J, Pilat J, Kaur H, Gu W, Kang S, Rusznak M, Huang H, Barrera J, Oloo P, Roland J, Hawkins C, Pahnke A, Khalil M, Washington M, Wilson K, Williams C, Peebles R, Konnikova L, Choksi Y, Hammer G, Lau K, Goettel J. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal Immunology 2025 PMID: 39988202, DOI: 10.1016/j.mucimm.2025.02.005.Peer-Reviewed Original ResearchInnate lymphoid cellsIL-10Lymphoid cellsImmune homeostasisInterleukin-10Population of innate lymphoid cellsIntestinal inflammationIntestinal macrophagesIL-10 receptor signalingModel of experimental colitisPromote immune homeostasisInterleukin-10 productionFluorescent protein reporterIL-10 productionIntestinal immune homeostasisCX3CR1-expressing cellsRNA in situ hybridizationCell-specific targetingAdoptive transferSpontaneous colitisProtein reporterIL10 deficiencyReporter miceImmune cellsImmunomodulatory cytokines
2018
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nature Communications 2018, 9: 1779. PMID: 29725003, PMCID: PMC5934380, DOI: 10.1038/s41467-018-03670-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell DifferentiationColitisGene DeletionGuanine Nucleotide Exchange FactorsHomeostasisHumansImmunity, MucosalInflammationInterleukin-10Interleukin-1betaInterleukin-23Intestinal MucosaMacrophagesMice, Inbred C57BLMice, TransgenicSignal TransductionWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome ProteinConceptsAnti-inflammatory macrophagesMucosal homeostasisMacrophage functionDevelopment of colitisAbsence of WASpColitis developmentAutoimmune sequelaeDendritic cellsIL-10Immune toleranceIntestinal homeostasisWiskott-Aldrich syndrome proteinMacrophagesMacrophage propertiesSTAT3 phosphorylationColitisExpression of WASPWASP deficiencyHomeostasisDOCK8SequelaeMice
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