Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions
Banou L, Sarrafpour S, Teng C, Liu J. Ocular Gene Therapy: An Overview of Viral Vectors, Immune Responses, and Future Directions. The Yale Journal Of Biology And Medicine 2024, 97: 491-503. PMID: 39703610, PMCID: PMC11650918, DOI: 10.59249/hwid7537.Peer-Reviewed Original ResearchConceptsAdeno-associated virusOcular gene therapyGene therapyFood and Drug AdministrationViral vectorsImmune responsePotential application of gene therapyClinical trialsApproval of voretigene neparvovecViral vector-based therapyApplication of gene therapyImproved delivery techniquesVector-based therapyImmune-privileged statusInduce immune responsesReduced immune responseVoretigene neparvovecContralateral eyeRetinal dystrophyImmune privilegeOcular diseasesDeliver genesEye diseaseTherapeutic efficacyTherapyExternal Disruption of Ocular Development in Utero
Kim H, Sarrafpour S, Teng C, Liu J. External Disruption of Ocular Development in Utero. The Yale Journal Of Biology And Medicine 2024, 97: 41-48. PMID: 38559457, PMCID: PMC10964818, DOI: 10.59249/rrmm8911.Peer-Reviewed Original ResearchConceptsOcular developmentOcular embryologyEnglish-language articlesIntrauterine infectionMaternal nutritionClinical significanceGenetic signaling pathwaysWeb of ScienceAnimal modelsHormonal factorsHuman studiesMultifactorial naturePregnancySignaling pathwayGoogle ScholarReviewIntrauterineEmbryologyLimited resourcesGestationUteroPathophysiologyFactorsInfectionPubMed
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