2024
Internal tremors and vibrations in long COVID: a cross-sectional study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal tremors and vibrations in long COVID: a cross-sectional study. The American Journal Of Medicine 2024 PMID: 39069199, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disordersCase-Control Study of Individuals With Small Fiber Neuropathy After COVID-19
McAlpine L, Zubair A, Joseph P, Spudich S. Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19. Neurology Neuroimmunology & Neuroinflammation 2024, 11: e200244. PMID: 38630952, PMCID: PMC11087026, DOI: 10.1212/nxi.0000000000200244.Peer-Reviewed Original ResearchConceptsInvasive cardiopulmonary exercise testingSmall fiber neuropathyCase-control studyFiber neuropathySkin biopsiesClinical response to treatmentNeurovascular dysregulationTreated with IVIGRetrospective chart reviewCase-control study of individualsRetrospective cohort studyResponse to treatmentCardiopulmonary exercise testingClass III evidenceMyalgic encephalomyelitis/chronic fatigue syndromeIVIG groupClinical responseNeuropathic symptomsChart reviewIVIGStudy of individualsCohort studyIII evidenceClinical trialsCOVID-19 illnessFocal White Matter Damage in Individuals with Cognitive Impairment After COVID-19 (P11-13.004)
McAlpine L, Nelson A, Chiarella J, Lacadie C, Farhadian S, Constable T, Spudich S. Focal White Matter Damage in Individuals with Cognitive Impairment After COVID-19 (P11-13.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204666.Peer-Reviewed Original ResearchVirology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis
Zubair A, McAlpine L, Gobeske K. Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis. Journal Of The Neurological Sciences 2024, 457: 122886. PMID: 38278094, DOI: 10.1016/j.jns.2024.122886.Peer-Reviewed Original Research
2023
Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation
Farhadian S, Reisert H, McAlpine L, Chiarella J, Kosana P, Yoon J, Spudich S. Self-Reported Neuropsychiatric Post–COVID-19 Condition and CSF Markers of Neuroinflammation. JAMA Network Open 2023, 6: e2342741. PMID: 37948085, PMCID: PMC10638645, DOI: 10.1001/jamanetworkopen.2023.42741.Peer-Reviewed Original ResearchPlasmapheresis Versus Intravenous Immunoglobulin in Patients With Autoimmune Neuromuscular and Neuro-immunological Conditions
Zubair A, Rethana M, Ma A, McAlpine L, Abulaban A, Munro B, Patwa H, Nowak R, Roy B. Plasmapheresis Versus Intravenous Immunoglobulin in Patients With Autoimmune Neuromuscular and Neuro-immunological Conditions. Journal Of Clinical Neuromuscular Disease 2023, 25: 11-17. PMID: 37611265, DOI: 10.1097/cnd.0000000000000439.Peer-Reviewed Original ResearchConceptsNeuro-immunological diseaseIntravenous immunoglobulinAutoimmune neurological disordersAutoimmune neuromuscular disorderAdult patientsElderly patientsNeurological disordersNeuromuscular disordersChronic inflammatory demyelinating polyradiculoneuropathyNational Inpatient Sample databaseNational Inpatient Sample datasetInflammatory demyelinating polyradiculoneuropathySafe therapeutic choiceRetrospective chart reviewAppropriate clinical settingSide effect profileDemyelinating polyradiculoneuropathyIVIG useChart reviewYounger patientsMyasthenia gravisEffect profileMedical historyPrimary diagnosisTherapeutic choiceNeurological sequelae of vaccines
McAlpine L, Zubair A. Neurological sequelae of vaccines. Neurological Sciences 2023, 44: 1505-1513. PMID: 36622478, PMCID: PMC9838503, DOI: 10.1007/s10072-022-06581-z.Peer-Reviewed Original ResearchConceptsGuillain-Barre syndromeInfectious diseasesNeurological sequelaeAcute disseminated encephalomyelitisSystemic immune activationMild adverse reactionsDisseminated encephalomyelitisLocal sorenessNeurologic sequelaeTransverse myelitisAdverse eventsRecent vaccinationImmune activationAdverse reactionsDisease onsetPotential pathogenesisSafe optionPotential treatmentEarly identificationVaccineSequelaeRapid diagnosisAdverse effectsTypical symptomsDisease
2022
Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin
McAlpine L, Lifland B, Check J, Angarita G, Ngo T, Chen P, Dandekar R, Alvarenga B, Browne W, Pleasure S, Wilson M, Spudich S, Farhadian S, Bartley C. Anti-SARS-CoV-2 and Autoantibody Profiling of a COVID-19 Patient With Subacute Psychosis Who Remitted After Treatment With Intravenous Immunoglobulin. Biological Psychiatry 2022, 93: e25-e29. PMID: 36481066, PMCID: PMC9722219, DOI: 10.1016/j.biopsych.2022.09.007.Peer-Reviewed Original ResearchIntravenous Immune Globulins vs Plasma Exchange Usage in Patients with Neuromuscular and Neuro-immunological Conditions (P4-13.007)
Rethana M, Zubair A, Ma A, McAlpine L, Abulaban A, Nowak R, Roy B. Intravenous Immune Globulins vs Plasma Exchange Usage in Patients with Neuromuscular and Neuro-immunological Conditions (P4-13.007). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.2392.Peer-Reviewed Original ResearchCase Series: Post-COVID Small Fiber Neuropathy (P9-9.002)
McAlpine L, Zubair A, Spudich S. Case Series: Post-COVID Small Fiber Neuropathy (P9-9.002). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.348.Peer-Reviewed Original Research
2021
Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients
McAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. Stroke 2021, 52: e233-e238. PMID: 33966492, PMCID: PMC8140646, DOI: 10.1161/strokeaha.120.031971.Peer-Reviewed Original ResearchDivergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms
Song E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Reports Medicine 2021, 2: 100288. PMID: 33969321, PMCID: PMC8091032, DOI: 10.1016/j.xcrm.2021.100288.Peer-Reviewed Original ResearchNeurological symptomsImmune responseCerebrospinal fluidAnti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesCOVID-19Self-reactive immune responsesSARS-CoV-2 antibodiesCompartmentalized immune responseCSF immunoglobulin GRole of autoimmunityCOVID-19 patientsB cell responsesCoronavirus disease 2019Immune surveyNeurologic sequelaePulmonary infectionBrain infectionSerum antibodiesDisease 2019Monoclonal antibody targetsAnimal modelsTarget epitopesCell activationCell responsesSingle-cell RNA sequencingIschemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402)
McAlpine L, Zubair A, Maran I, Chojecka P, Lleva P, Jasne A, Navaratnam D, Matouk C, Schindler J, Chun H, Lee A, Spudich S, Sharma R, Sansing L. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients (2402). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.2402.Peer-Reviewed Original ResearchIsolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup Strategies
McAlpine LS, Barden M, Zubair AS, Sanamandra S. Isolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup Strategies. Cureus 2021, 13: e13277. PMID: 33728212, PMCID: PMC7955529, DOI: 10.7759/cureus.13277.Peer-Reviewed Case Reports and Technical NotesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2COVID-19 patientsSyndrome coronavirus 2Common COVID-19 symptomsCOVID-19 symptomsHuman coronavirus disease 2019Coronavirus disease 2019Multiple organ systemsCOVID-19Neurologic examinationRespiratory dysfunctionCoronavirus 2Disease 2019Respiratory diseaseSevere diseaseSensory examinationWorkup strategiesCase presentationCognitive declineOrgan systemsIntact motorDiseasePatients
2020
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S. Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? Current Opinion In Psychiatry 2020, 34: 177-185. PMID: 33395100, PMCID: PMC7924921, DOI: 10.1097/yco.0000000000000688.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019Multiple sclerosisParkinson's diseaseNeurodegenerative diseasesAlzheimer's diseaseDisease 2019High riskCOVID-19Heart/lung diseaseHigh-risk comorbid conditionsHospitalized COVID-19 patientsAltered mental statusCOVID-19 patientsMS patientsSuch patientsComorbid conditionsNeurological symptomsPoor outcomeLung diseaseMental statusAdvanced ageSevere diseasePatientsBetter outcomesViral infectionLessons from a neurology consult service for patients with COVID-19
McAlpine LS, Zubair AS, Moeller J, Baehring J, Spudich S. Lessons from a neurology consult service for patients with COVID-19. The Lancet Neurology 2020, 19: 806-807. PMID: 32949536, PMCID: PMC7494315, DOI: 10.1016/s1474-4422(20)30316-1.Peer-Reviewed Case Reports and Technical NotesNeuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019
Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019. JAMA Neurology 2020, 77: 1018-1027. PMID: 32469387, PMCID: PMC7484225, DOI: 10.1001/jamaneurol.2020.2065.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous systemCoronavirus disease 2019Nervous systemDisease 2019Respiratory syndromeCOVID-19Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Long-term neurologic sequelaeRespiratory syndrome coronavirus 2Middle East respiratory syndromeSevere acute respiratory syndromeClinical neurological complicationsFurther neuropathological studiesBest treatment algorithmImproved clinical outcomesBlood-brain barrierImpairment of consciousnessSyndrome coronavirus 2Peripheral nervous systemAcute respiratory syndromeHuman coronavirus disease 2019Common neurologic complaintsSARS-CoV-2Neurologic sequelae