2025
Optimal approach to performing and reporting computed tomography angiography for suspected acute pulmonary embolism: a clinical consensus statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute CardioVascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR)
Klok F, Barco S, Bertoletti L, Bhalla S, Dubois S, Le Gal G, Haramati L, van Hooidonk E, Humbert M, Konstantinides S, Lang I, Murphy W, Ohno Y, Price S, Prokop M, Pruszczyk P, Rossi A, Thistlethwaite P, West C, Remy-Jardin M. Optimal approach to performing and reporting computed tomography angiography for suspected acute pulmonary embolism: a clinical consensus statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute CardioVascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR). European Heart Journal - Cardiovascular Imaging 2025, 26: 1085-1098. PMID: 40457988, DOI: 10.1093/ehjci/jeaf050.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologyEuropean Association of Cardiovascular ImagingComputed tomography angiographySociety of Thoracic RadiologyEuropean Society of Thoracic ImagingAcute pulmonary embolismRight ventricular functionPulmonary embolismClinical consensus statementEuropean Respiratory SocietyPE patientsVentricular functionComputed tomography angiography reportsDiagnosing acute pulmonary embolismSuspected acute pulmonary embolismComputed tomography angiography findingsConsensus statementThoracic radiologyCardiovascular imagingEuropean Society of Cardiology Working GroupFleischner SocietyEuropean AssociationCT imaging findingsSociety of CardiologyEuropean SocietyOptimal Approach to Performing and Reporting Computed Tomography Angiography for Suspected Acute Pulmonary Embolism: A Clinical Consensus Statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute Cardiovascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, Endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR).
Klok F, Barco S, Bertoletti L, Bhalla S, Dubois S, Le Gal G, Haramati L, van Hooidonk E, Humbert M, Konstantinides S, Lang I, Murphy W, Ohno Y, Price S, Prokop M, Pruszczyk P, Rossi A, Thistlethwaite P, West C, Remy-Jardin M. Optimal Approach to Performing and Reporting Computed Tomography Angiography for Suspected Acute Pulmonary Embolism: A Clinical Consensus Statement of the ESC Working Group on Pulmonary Circulation & Right Ventricular Function, the Fleischner Society, the Association for Acute Cardiovascular Care (ACVC) and the European Association of Cardiovascular Imaging (EACVI) of the ESC, Endorsed by European Respiratory Society (ERS), Asian Society of Thoracic Radiology (ASTR), European Society of Thoracic Imaging (ESTI), and Society of Thoracic Radiology (STR). Radiology 2025, 315: e243833. PMID: 40459417, DOI: 10.1148/radiol.243833.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologyEuropean Association of Cardiovascular ImagingSociety of Thoracic RadiologyEuropean Society of Thoracic ImagingAcute pulmonary embolismRight ventricular functionCT angiographyPulmonary embolismClinical consensus statementEuropean Respiratory SocietyPE patientsVentricular functionDiagnosing acute pulmonary embolismSuspected acute pulmonary embolismConsensus statementThoracic radiologyCardiovascular imagingEuropean Society of Cardiology Working GroupFleischner SocietyEuropean AssociationCT angiography findingsCT imaging findingsComputed tomography angiographyCT angiography reportsSociety of CardiologyLong-term mortality from imaging-diagnosed pulmonary embolism in women and men
Sosner E, Mathai B, Bordon A, Ye K, Moadel R, Haramati L, Lazarus M. Long-term mortality from imaging-diagnosed pulmonary embolism in women and men. Clinical Imaging 2025, 122: 110469. PMID: 40273669, DOI: 10.1016/j.clinimag.2025.110469.Peer-Reviewed Original ResearchConceptsElectronic health recordsOne-year mortalityIncreased one-year mortalityCox proportional hazards modelsCharlson Comorbidity IndexProportional hazards modelLong-term mortalityUrban academic medical centerNational Death IndexMortality of womenHazards modelAcademic medical centerStudy of adultsHigher hazard ratioHealth recordsDeath IndexHealth statusInclusion of ageImpact of PEHazard ratioRetrospective study of adultsMedical CenterRisk factorsComorbidity indexPulmonary embolism
2022
Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism
Chan J, Ho B, Ye K, Haramati L, Jain V. Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism. Journal Of Computer Assisted Tomography 2022, 46: 888-893. PMID: 36399535, DOI: 10.1097/rct.0000000000001372.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansLungMaleMiddle AgedPulmonary ArteryPulmonary EmbolismThoraxTomography, X-Ray ComputedConceptsPulmonary embolismPulmonary artery enhancementContrast-enhanced chest CT scansHU thresholdContrast-enhanced chest CTAbsence of PEUnsuspected pulmonary embolismContrast-enhanced chestHounsfield unitsChest CT scanLogistic regression analysisPeripheral enhancementPulmonary vasculatureChest CTFemale sexRoutine chestContrast amountCT scanPulmonary enhancementTotal casesOlder ageEmbolismRegression analysisChestDescriptive statistics
2021
Pulmonary CTA Reporting: AJR Expert Panel Narrative Review.
Tan S, Nance J, Haramati L, Rajiah P, Sherk W, Le Gal G, Stojanovska J. Pulmonary CTA Reporting: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2021, 218: 396-404. PMID: 34612678, DOI: 10.2214/ajr.21.26646.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary CTANarrative reviewAJR Expert Panel Narrative ReviewInvasive managementOutpatient basisSignificant thrombusFatal conditionCTA reportsClinical significanceAppropriate managementMedical teamPractice settingsInsignificant findingsRadiology reportsPertinent findingsCTARelevant findingsReportFindingsEmbolismReviewThrombusUbiquitous studiesExperience with a perfusion-only screening protocol for evaluation of pulmonary embolism during the COVID-19 pandemic surge.
Kumar A, Moadel R, Haramati L, Ye K, Freeman L, Zuckier L. Experience with a perfusion-only screening protocol for evaluation of pulmonary embolism during the COVID-19 pandemic surge. Journal Of Nuclear Medicine 2021, 63: jnumed.121.262580. PMID: 34353874, PMCID: PMC8973288, DOI: 10.2967/jnumed.121.262580.Peer-Reviewed Original ResearchConceptsPandemic surgeCOVID-19 negative patientsCOVID-19 pandemic surgeSegmental perfusion defectsCOVID-19 patientsCOVID-19 surgeHospital dischargePulmonary embolismLung scintigraphyFinal diagnosisPerfusion defectsClinical dataNormal resultsLung opacitiesLower mortalityPatientsPOS resultsStudy periodAdditional examinationDemographic informationElectronic recordsPerfusionAlternative testingEmbolismScintigraphySystematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins C, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates S, Lang E, Le Gal G, Haramati L, Kline J, Righini M, Wiercioch W, SchĂĽnemann H, Mustafa R. Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism. Blood Advances 2021, 5: 2237-2244. PMID: 33900385, PMCID: PMC8095140, DOI: 10.1182/bloodadvances.2020002398.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhageHumansIncidencePulmonary EmbolismTomography, X-Ray ComputedVenous ThromboembolismConceptsIncidence of VTENegative D-dimerPulmonary embolismVenous thromboembolismPretest probabilityMajor bleedingD-dimerNegative computed tomography scanRecurrent venous thromboembolismCochrane Central RegisterRecurrent pulmonary embolismLow pretest probabilityIntermediate pretest probabilityRelevant conference proceedingsComputed tomography scanHigh pretest probabilityPostthrombotic sequelaeCause mortalityCentral RegisterControlled TrialsIntracranial hemorrhagePrompt evaluationDiagnostic pathwayEligible studiesTomography scan
2020
Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Wiercioch W, Varghese J, Wooldridge D, Alturkmani H, Thomas M, Baig M, Bahaj W, Khatib R, Kehar R, Ponnapureddy R, Sethi A, Mustafa A, Lim W, Le Gal G, Bates S, Haramati L, Kline J, Lang E, Righini M, Kalot M, Husainat N, Jabiri Y, SchĂĽnemann H, Mustafa R. Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism. Blood Advances 2020, 4: 4296-4311. PMID: 32915980, PMCID: PMC7509887, DOI: 10.1182/bloodadvances.2019001052.Peer-Reviewed Original ResearchMeSH KeywordsHumansPulmonary EmbolismRadionuclide ImagingSensitivity and SpecificityUltrasonographyVentilation-Perfusion ScanConceptsPulmonary embolismCompression ultrasonographyPooled estimatesQ scanSystematic reviewRecurrent pulmonary embolismVentilation-perfusion scanningCertainty of evidenceRelevant conference proceedingsRisk of biasOptimal patient managementD-dimer sensitivityD-dimer assayDiagnostic Accuracy Studies-2Recommendations AssessmentPrompt diagnosisTomography pulmonaryD-dimerCochrane CENTRALTreatable conditionEligible studiesPatient managementReference listsTherapeutic interventionsRelevant reviewsDiagnostic Performance of Pulmonary Embolism Imaging in Patients with History of Asthma.
Lazarus M, Kim Y, Mathai B, Levsky J, Freeman L, Haramati L, Moadel R. Diagnostic Performance of Pulmonary Embolism Imaging in Patients with History of Asthma. Journal Of Nuclear Medicine 2020, 62: 399-404. PMID: 32680927, DOI: 10.2967/jnumed.120.242776.Peer-Reviewed Original ResearchConceptsHistory of asthmaPulmonary embolismFalse negative rateRepeat examsDiagnostic performanceChronic lung diseaseVentilation-perfusion scanningHigh false-negative rateLung diseaseCT pulmonaryNegative imagingNondiagnostic resultsVentilation defectsAsthmaCTPANegative casesEmbolismPatientsHigh rateAdultsExamPulmonaryHistorySymptomsDiseaseReply: COVID-19 and Pulmonary Embolism: Diagnostic Imaging Trends
Zuckier L, Moadel R, Haramati L, Freeman L. Reply: COVID-19 and Pulmonary Embolism: Diagnostic Imaging Trends. Journal Of Nuclear Medicine 2020, 61: 1102-1103. PMID: 32576640, DOI: 10.2967/jnumed.120.250530.Peer-Reviewed Original ResearchDiagnostic evaluation of pulmonary embolism during the COVID-19 pandemic
Zuckier L, Moadel R, Haramati L, Freeman L. Diagnostic evaluation of pulmonary embolism during the COVID-19 pandemic. Journal Of Nuclear Medicine 2020, 61: jnumed.120.245571. PMID: 32238427, DOI: 10.2967/jnumed.120.245571.Peer-Reviewed Original ResearchImaging of Chronic Thromboembolic Disease
Haramati A, Haramati L. Imaging of Chronic Thromboembolic Disease. Lung 2020, 198: 245-255. PMID: 32166427, DOI: 10.1007/s00408-020-00344-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsDiagnosis, DifferentialHumansHypertension, PulmonaryLungMultimodal ImagingPulmonary EmbolismConceptsChronic thromboembolic pulmonary hypertensionChronic pulmonary embolismChronic thromboembolic diseaseAcute pulmonary embolismPulmonary embolismPulmonary hypertensionThromboembolic diseaseVentilation/perfusion scanCommon long-term complicationThromboembolic pulmonary hypertensionLong-term complicationsMultimodality imaging featuresRelevant imaging findingsImaging mimicsCardiovascular morbidityPersistent symptomsImaging findingsCharacteristic findingsPerfusion scanImaging featuresLeading causeCT scanRare diseaseTreatable typeEmbolism
2018
American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism
Lim W, Le Gal G, Bates S, Righini M, Haramati L, Lang E, Kline J, Chasteen S, Snyder M, Patel P, Bhatt M, Patel P, Braun C, Begum H, Wiercioch W, SchĂĽnemann H, Mustafa R. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Advances 2018, 2: 3226-3256. PMID: 30482764, PMCID: PMC6258916, DOI: 10.1182/bloodadvances.2018024828.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDeep vein thrombosisRecurrent venous thromboembolismExtremity deep vein thrombosisVenous thromboembolismPulmonary embolismVTE riskUpper extremity deep vein thrombosisLower extremity deep vein thrombosisMcMaster University GRADE CentreDiagnostic strategiesHematology 2018 guidelinesHigh VTE riskLower VTE riskPretest probability assessmentTomography pulmonary angiographyVentilation-perfusion scanningClinical decision ruleEvidence-based guidelinesNew diagnostic modalitiesHealth care professionalsAmerican SocietyModern diagnostic strategiesVTE diagnosisVTE prevalenceRecommendations AssessmentAre We Overdiagnosing Pulmonary Embolism? Yes!
Tan S, Haramati L. Are We Overdiagnosing Pulmonary Embolism? Yes! Journal Of Thoracic Imaging 2018, 33: 346-347. PMID: 30239459, DOI: 10.1097/rti.0000000000000365.Commentaries, Editorials and LettersNavigating the Pulmonary Perfusion Map
Alis J, Latson L, Haramati L, Shmukler A. Navigating the Pulmonary Perfusion Map. Journal Of Computer Assisted Tomography 2018, 42: 840-849. PMID: 30371612, DOI: 10.1097/rct.0000000000000801.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPulmonary embolismCommon acute cardiovascular diseaseComputed tomography pulmonary angiographyAcute pulmonary embolismTomography pulmonary angiographyAcute cardiovascular diseaseTomography perfusion imagingAcute PEVascular causesPulmonary angiographyPerfusion defectsCardiovascular diseaseCommon causePulmonary perfusionFunctional assessmentHigh-resolution morphological informationPerfusion imagingPerfusion mapsEmbolismUnderstanding of physiologyCauseAngiographyPathophysiologyPerfusionDiseaseImaging of suspected pulmonary embolism and deep venous thrombosis in obese patients
Cascio V, Hon M, Haramati L, Gour A, Spiegler P, Bhalla S, Katz D. Imaging of suspected pulmonary embolism and deep venous thrombosis in obese patients. British Journal Of Radiology 2018, 91: 20170956. PMID: 29762047, PMCID: PMC6223165, DOI: 10.1259/bjr.20170956.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDeep venous thrombosisPulmonary embolismObese patientsVenous thrombosisTreatment of DVTDiagnosis of DVTPatient sizeSetting of obesityHigh-level evidenceLarge patient sizeLean patientsVenous thromboembolismThromboembolic diseaseAlternative diagnosesContrast dosingPatientsClinical sitesRadiation exposureDiagnosisEmbolismThrombosisObesityMore researchExaminationCurrent understandingImaging for Pulmonary Embolism in Sickle Cell Disease: A 17-Year Experience
Tivnan P, Billett H, Freeman L, Haramati L. Imaging for Pulmonary Embolism in Sickle Cell Disease: A 17-Year Experience. Journal Of Nuclear Medicine 2018, 59: 1255-1259. PMID: 29419477, DOI: 10.2967/jnumed.117.205641.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemia, Sickle CellComputed Tomography AngiographyFemaleHumansMalePulmonary EmbolismRetrospective StudiesVentilation-Perfusion RatioConceptsSickle cell diseaseSickle cell disease patientsPulmonary embolismNormal chest radiographPulmonary embolism diagnosisCell diseaseChoice of imagingChest radiographsDisease patientsChest radiographyStudy periodChest radiographic resultsVentilation-perfusion scintigraphyReasonable first choicePulmonary embolism imagingPulmonary complicationsRetrospective cohortStable patientsClinical presentationRadiographic resultsMean ageCT pulmonaryEmbolismIndeterminate resultsComparable diagnostic performance
2017
Patent foramen ovale in patients with pulmonary embolism: A prognostic factor on CT pulmonary angiography?
Zhang M, Tan S, Patel V, Zalta B, Shmukler A, Levsky J, Jain V, Shaban N, Haramati L. Patent foramen ovale in patients with pulmonary embolism: A prognostic factor on CT pulmonary angiography? Journal Of Cardiovascular Computed Tomography 2017, 12: 271-274. PMID: 29217343, DOI: 10.1016/j.jcct.2017.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyEchocardiographyFemaleForamen Ovale, PatentHumansMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrevalencePrognosisPulmonary ArteryPulmonary EmbolismReproducibility of ResultsRetrospective StudiesRisk FactorsTime FactorsYoung AdultConceptsAcute pulmonary embolismRight heart strainPulmonary embolismTransthoracic echocardiogramHeart strainPatent foramenRight ventricularCT pulmonaryCT signsExact testVentricular diameter ratioRoutine transthoracic echocardiogramFischer's exact testYears of experiencePFO prevalenceSeptal bowingPrognostic factorsContrast refluxRetrospective studyRisk factorsMedical CenterMAIN OUTCOMEPopulation prevalencePatientsAdvanced imagingPerformance of a simple robust empiric timing protocol for CT pulmonary angiography
Hsu K, Levsky J, Haramati L, Gohari A. Performance of a simple robust empiric timing protocol for CT pulmonary angiography. Clinical Imaging 2017, 48: 17-21. PMID: 29024836, DOI: 10.1016/j.clinimag.2017.09.006.Peer-Reviewed Original ResearchConceptsPulmonary arteryLower radiation exposureTiming groupsRadiation exposureBolus groupAortic enhancementCT pulmonary angiographySimilar mean ageResults of CTPAConsecutive CTPAsEmpiric protocolPatient characteristicsPulmonary angiographyRetrospective reviewMean ageBolus protocolPositivity rateHigh diagnostic qualityArteryDiagnostic quality imagesBolus methodCTPATiming bolusProtocol changesAortaPerformance of Low-Dose Perfusion Scintigraphy and CT Pulmonary Angiography for Pulmonary Embolism in Pregnancy
Sheen JJ, Haramati LB, Natenzon A, Ma H, Tropper P, Bader AS, Freeman LM, Bernstein PS, Moadel RM. Performance of Low-Dose Perfusion Scintigraphy and CT Pulmonary Angiography for Pulmonary Embolism in Pregnancy. CHEST Journal 2017, 153: 152-160. PMID: 28823756, DOI: 10.1016/j.chest.2017.08.005.Peer-Reviewed Original ResearchConceptsNegative predictive valuePulmonary embolismPregnant womenSubgroup analysisChest radiographsRadiation exposureRetrospective cohort studyInitial imaging modalityCT pulmonary angiographyMontefiore Medical CenterFirst-choice modalityNegative resultsVTE diagnosisPregnant patientsCohort studyNormal pregnancyPerfusion scanningPrimary outcomeInitial imagingPulmonary angiographyPerfusion scintigraphyUncommon diagnosisCT pulmonaryMedical CenterNegative studies
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