2024
Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification
Friedman R, Haramati L, Christian T, Sokol S, Alis J. Heart lung axis in acute pulmonary embolism: Role of CT in risk stratification. Clinical Imaging 2024, 116: 110311. PMID: 39413674, DOI: 10.1016/j.clinimag.2024.110311.Peer-Reviewed Original ResearchPathophysiology of pulmonary embolismRisk stratificationPulmonary embolismComputed tomographyRight ventricular (RV) dysfunctionRisk stratification of acute PEIndicator of RV dysfunctionRV/LV diameter ratioAcute pulmonary embolismLeft atrial volumeReview current guidelinesCause of mortalityRV dysfunctionAcute PEAtrial volumeCT findingsClot burdenCardiopulmonary reserveCurrent guidelinesLung axisClot locationPatient managementPatient populationRadiologist's reportPredictive value
2023
CT in Pulmonary Embolism
Alis J, Haramati L. CT in Pulmonary Embolism. 2023, 1-22. DOI: 10.1007/978-3-030-70904-4_64-1.ChaptersRight ventricular/left ventricular diameter ratioEvaluation of acute PEPrognostic value of CTMethods of risk stratificationVentricular diameter ratioCT pulmonary angiographyValue of CTChronic PEPulmonary angiographyAcute PEObstruction scorePrognostic valuePulmonary embolismRisk stratificationClot locationPerfusion mapsDiagnostic studies
2022
Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism
Chan J, Ho B, Ye K, Haramati L, Jain V. Using Routine Chest Computed Tomography to Diagnose Pulmonary Embolism. Journal Of Computer Assisted Tomography 2022, 46: 888-893. PMID: 36399535, DOI: 10.1097/rct.0000000000001372.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary artery enhancementContrast-enhanced chest CT scansHU thresholdContrast-enhanced chest CTAbsence of PEUnsuspected pulmonary embolismContrast-enhanced chestHounsfield unitsChest CT scanLogistic regression analysisPeripheral enhancementPulmonary vasculatureChest CTFemale sexRoutine chestContrast amountCT scanPulmonary enhancementTotal casesOlder ageEmbolismRegression analysisChestDescriptive statistics
2021
Pulmonary CTA Reporting: AJR Expert Panel Narrative Review.
Tan S, Nance J, Haramati L, Rajiah P, Sherk W, Le Gal G, Stojanovska J. Pulmonary CTA Reporting: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2021, 218: 396-404. PMID: 34612678, DOI: 10.2214/ajr.21.26646.Peer-Reviewed Original ResearchConceptsPulmonary embolismPulmonary CTANarrative reviewAJR Expert Panel Narrative ReviewInvasive managementOutpatient basisSignificant thrombusFatal conditionCTA reportsClinical significanceAppropriate managementMedical teamPractice settingsInsignificant findingsRadiology reportsPertinent findingsCTARelevant findingsReportFindingsEmbolismReviewThrombusUbiquitous studiesExperience with a perfusion-only screening protocol for evaluation of pulmonary embolism during the COVID-19 pandemic surge.
Kumar A, Moadel R, Haramati L, Ye K, Freeman L, Zuckier L. Experience with a perfusion-only screening protocol for evaluation of pulmonary embolism during the COVID-19 pandemic surge. Journal Of Nuclear Medicine 2021, 63: jnumed.121.262580. PMID: 34353874, PMCID: PMC8973288, DOI: 10.2967/jnumed.121.262580.Peer-Reviewed Original ResearchConceptsPandemic surgeCOVID-19 negative patientsCOVID-19 pandemic surgeSegmental perfusion defectsCOVID-19 patientsCOVID-19 surgeHospital dischargePulmonary embolismLung scintigraphyFinal diagnosisPerfusion defectsClinical dataNormal resultsLung opacitiesLower mortalityPatientsPOS resultsStudy periodAdditional examinationDemographic informationElectronic recordsPerfusionAlternative testingEmbolismScintigraphySystematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins C, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates S, Lang E, Le Gal G, Haramati L, Kline J, Righini M, Wiercioch W, Schünemann H, Mustafa R. Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism. Blood Advances 2021, 5: 2237-2244. PMID: 33900385, PMCID: PMC8095140, DOI: 10.1182/bloodadvances.2020002398.Peer-Reviewed Original ResearchConceptsIncidence of VTENegative D-dimerPulmonary embolismVenous thromboembolismPretest probabilityMajor bleedingD-dimerNegative computed tomography scanRecurrent venous thromboembolismCochrane Central RegisterRecurrent pulmonary embolismLow pretest probabilityIntermediate pretest probabilityRelevant conference proceedingsComputed tomography scanHigh pretest probabilityPostthrombotic sequelaeCause mortalityCentral RegisterControlled TrialsIntracranial hemorrhagePrompt evaluationDiagnostic pathwayEligible studiesTomography scan
2020
Establishing diagnostic criteria and treatment of subsegmental pulmonary embolism: A Delphi analysis of experts
den Exter P, Kroft L, Gonsalves C, Le Gal G, Schaefer‐Prokop C, Carrier M, Huisman M, Klok F, Meijboom L, Beenen L, de Roos A, Hartmann I, Dennie C, Revel M, Haramati L, van Beek E, Screaton N, Ferretti G, Ghaye B, Das M, White C, Pena Fernandez E, Paul N, Vlahos I, Renapurkar R, Ravenel J, Kanne J, Abbara S, Rémy‐Jardin M, Geurts B, Frauenfelder T, Sverzellati N, Prosch H, Goo J, Vogel‐Claussen J, MacMahon P, Bhalla S, Kahn S, Shivakumar S, Wells P, Rodger M, Castellucci L, Duffett L, Delluc A, Siegal D, Lazo‐Langner A, Wu C, Lee A, Garcia D, Zwicker J, Aujesky D, Jimenez D, Righini M, Blondon M, Ay C, Barco S, Kamphuisen P, Ferreira M, Sanchez O, Moores L, Tromeur C, Ageno W, Hunt B, Prandoni P, Monreal M, Crowther M, Roy P, Pabinger I, Donadini M, Moustafa F, Jara‐Palomares L, Pedroc R, Bertoletti L, Verhamme P, Eikenboom H, van der Meer F, Büller H, van Es N. Establishing diagnostic criteria and treatment of subsegmental pulmonary embolism: A Delphi analysis of experts. Research And Practice In Thrombosis And Haemostasis 2020, 4: e12422. PMID: 33313465, PMCID: PMC7695556, DOI: 10.1002/rth2.12422.Peer-Reviewed Original ResearchSubsegmental pulmonary embolismDiagnostic criteriaAnticoagulant treatmentPulmonary embolismProximal deep vein thrombosisStandard radiological criteriaDeep vein thrombosisClinical expert panelUniform diagnostic criteriaLow interobserver agreementExpert thoracic radiologistsPrior VTEAntiphospholipid syndromeVenous thromboembolismVein thrombosisBenign presentationArtery diameterRadiological criteriaClinical trialsSubsegmental arteriesExpert consensusSSPEThoracic radiologistsLevel of agreementInterobserver agreementSystematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Wiercioch W, Varghese J, Wooldridge D, Alturkmani H, Thomas M, Baig M, Bahaj W, Khatib R, Kehar R, Ponnapureddy R, Sethi A, Mustafa A, Lim W, Le Gal G, Bates S, Haramati L, Kline J, Lang E, Righini M, Kalot M, Husainat N, Jabiri Y, Schünemann H, Mustafa R. Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism. Blood Advances 2020, 4: 4296-4311. PMID: 32915980, PMCID: PMC7509887, DOI: 10.1182/bloodadvances.2019001052.Peer-Reviewed Original ResearchConceptsPulmonary embolismCompression ultrasonographyPooled estimatesQ scanSystematic reviewRecurrent pulmonary embolismVentilation-perfusion scanningCertainty of evidenceRelevant conference proceedingsRisk of biasOptimal patient managementD-dimer sensitivityD-dimer assayDiagnostic Accuracy Studies-2Recommendations AssessmentPrompt diagnosisTomography pulmonaryD-dimerCochrane CENTRALTreatable conditionEligible studiesPatient managementReference listsTherapeutic interventionsRelevant reviewsDiagnostic Performance of Pulmonary Embolism Imaging in Patients with History of Asthma.
Lazarus M, Kim Y, Mathai B, Levsky J, Freeman L, Haramati L, Moadel R. Diagnostic Performance of Pulmonary Embolism Imaging in Patients with History of Asthma. Journal Of Nuclear Medicine 2020, 62: 399-404. PMID: 32680927, DOI: 10.2967/jnumed.120.242776.Peer-Reviewed Original ResearchConceptsHistory of asthmaPulmonary embolismFalse negative rateRepeat examsDiagnostic performanceChronic lung diseaseVentilation-perfusion scanningHigh false-negative rateLung diseaseCT pulmonaryNegative imagingNondiagnostic resultsVentilation defectsAsthmaCTPANegative casesEmbolismPatientsHigh rateAdultsExamPulmonaryHistorySymptomsDiseaseImaging of Chronic Thromboembolic Disease
Haramati A, Haramati L. Imaging of Chronic Thromboembolic Disease. Lung 2020, 198: 245-255. PMID: 32166427, DOI: 10.1007/s00408-020-00344-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic thromboembolic pulmonary hypertensionChronic pulmonary embolismChronic thromboembolic diseaseAcute pulmonary embolismPulmonary embolismPulmonary hypertensionThromboembolic diseaseVentilation/perfusion scanCommon long-term complicationThromboembolic pulmonary hypertensionLong-term complicationsMultimodality imaging featuresRelevant imaging findingsImaging mimicsCardiovascular morbidityPersistent symptomsImaging findingsCharacteristic findingsPerfusion scanImaging featuresLeading causeCT scanRare diseaseTreatable typeEmbolism
2018
American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism
Lim W, Le Gal G, Bates S, Righini M, Haramati L, Lang E, Kline J, Chasteen S, Snyder M, Patel P, Bhatt M, Patel P, Braun C, Begum H, Wiercioch W, Schünemann H, Mustafa R. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Advances 2018, 2: 3226-3256. PMID: 30482764, PMCID: PMC6258916, DOI: 10.1182/bloodadvances.2018024828.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDeep vein thrombosisRecurrent venous thromboembolismExtremity deep vein thrombosisVenous thromboembolismPulmonary embolismVTE riskUpper extremity deep vein thrombosisLower extremity deep vein thrombosisMcMaster University GRADE CentreDiagnostic strategiesHematology 2018 guidelinesHigh VTE riskLower VTE riskPretest probability assessmentTomography pulmonary angiographyVentilation-perfusion scanningClinical decision ruleEvidence-based guidelinesNew diagnostic modalitiesHealth care professionalsAmerican SocietyModern diagnostic strategiesVTE diagnosisVTE prevalenceRecommendations AssessmentAre We Overdiagnosing Pulmonary Embolism? Yes!
Tan S, Haramati L. Are We Overdiagnosing Pulmonary Embolism? Yes! Journal Of Thoracic Imaging 2018, 33: 346-347. PMID: 30239459, DOI: 10.1097/rti.0000000000000365.Commentaries, Editorials and LettersNavigating the Pulmonary Perfusion Map
Alis J, Latson L, Haramati L, Shmukler A. Navigating the Pulmonary Perfusion Map. Journal Of Computer Assisted Tomography 2018, 42: 840-849. PMID: 30371612, DOI: 10.1097/rct.0000000000000801.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPulmonary embolismCommon acute cardiovascular diseaseComputed tomography pulmonary angiographyAcute pulmonary embolismTomography pulmonary angiographyAcute cardiovascular diseaseTomography perfusion imagingAcute PEVascular causesPulmonary angiographyPerfusion defectsCardiovascular diseaseCommon causePulmonary perfusionFunctional assessmentHigh-resolution morphological informationPerfusion imagingPerfusion mapsEmbolismUnderstanding of physiologyCauseAngiographyPathophysiologyPerfusionDiseaseImaging of suspected pulmonary embolism and deep venous thrombosis in obese patients
Cascio V, Hon M, Haramati L, Gour A, Spiegler P, Bhalla S, Katz D. Imaging of suspected pulmonary embolism and deep venous thrombosis in obese patients. British Journal Of Radiology 2018, 91: 20170956. PMID: 29762047, PMCID: PMC6223165, DOI: 10.1259/bjr.20170956.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDeep venous thrombosisPulmonary embolismObese patientsVenous thrombosisTreatment of DVTDiagnosis of DVTPatient sizeSetting of obesityHigh-level evidenceLarge patient sizeLean patientsVenous thromboembolismThromboembolic diseaseAlternative diagnosesContrast dosingPatientsClinical sitesRadiation exposureDiagnosisEmbolismThrombosisObesityMore researchExaminationCurrent understandingAcute Pulmonary Embolism in Adults and Children: Evidence-Based Emergency Imaging, Evaluation, and Diagnosis
Haramati L, Patel V, Freeman L, Thacker P, Lee E. Acute Pulmonary Embolism in Adults and Children: Evidence-Based Emergency Imaging, Evaluation, and Diagnosis. Evidence-Based Imaging 2018, 227-245. DOI: 10.1007/978-3-319-67066-9_16.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcute pulmonary embolismPulmonary embolismEvidence-Based Emergency ImagingEvidence-based diagnostic algorithmPulmonary embolism diagnosisDate medical literatureClinical presentationEmergency ImagingHigh morbidityClinical assessmentMortality burdenPretest probabilityEmbolismAccurate diagnosisMedical literatureDiagnostic algorithmCommon diseaseDiagnosisImaging modalitiesMorbidityPregnancyDiseaseImportant roleImaging for Pulmonary Embolism in Sickle Cell Disease: A 17-Year Experience
Tivnan P, Billett H, Freeman L, Haramati L. Imaging for Pulmonary Embolism in Sickle Cell Disease: A 17-Year Experience. Journal Of Nuclear Medicine 2018, 59: 1255-1259. PMID: 29419477, DOI: 10.2967/jnumed.117.205641.Peer-Reviewed Original ResearchConceptsSickle cell diseaseSickle cell disease patientsPulmonary embolismNormal chest radiographPulmonary embolism diagnosisCell diseaseChoice of imagingChest radiographsDisease patientsChest radiographyStudy periodChest radiographic resultsVentilation-perfusion scintigraphyReasonable first choicePulmonary embolism imagingPulmonary complicationsRetrospective cohortStable patientsClinical presentationRadiographic resultsMean ageCT pulmonaryEmbolismIndeterminate resultsComparable diagnostic performance
2017
Patent foramen ovale in patients with pulmonary embolism: A prognostic factor on CT pulmonary angiography?
Zhang M, Tan S, Patel V, Zalta B, Shmukler A, Levsky J, Jain V, Shaban N, Haramati L. Patent foramen ovale in patients with pulmonary embolism: A prognostic factor on CT pulmonary angiography? Journal Of Cardiovascular Computed Tomography 2017, 12: 271-274. PMID: 29217343, DOI: 10.1016/j.jcct.2017.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overComputed Tomography AngiographyEchocardiographyFemaleForamen Ovale, PatentHumansMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrevalencePrognosisPulmonary ArteryPulmonary EmbolismReproducibility of ResultsRetrospective StudiesRisk FactorsTime FactorsYoung AdultConceptsAcute pulmonary embolismRight heart strainPulmonary embolismTransthoracic echocardiogramHeart strainPatent foramenRight ventricularCT pulmonaryCT signsExact testVentricular diameter ratioRoutine transthoracic echocardiogramFischer's exact testYears of experiencePFO prevalenceSeptal bowingPrognostic factorsContrast refluxRetrospective studyRisk factorsMedical CenterMAIN OUTCOMEPopulation prevalencePatientsAdvanced imagingPerformance of Low-Dose Perfusion Scintigraphy and CT Pulmonary Angiography for Pulmonary Embolism in Pregnancy
Sheen JJ, Haramati LB, Natenzon A, Ma H, Tropper P, Bader AS, Freeman LM, Bernstein PS, Moadel RM. Performance of Low-Dose Perfusion Scintigraphy and CT Pulmonary Angiography for Pulmonary Embolism in Pregnancy. CHEST Journal 2017, 153: 152-160. PMID: 28823756, DOI: 10.1016/j.chest.2017.08.005.Peer-Reviewed Original ResearchConceptsNegative predictive valuePulmonary embolismPregnant womenSubgroup analysisChest radiographsRadiation exposureRetrospective cohort studyInitial imaging modalityCT pulmonary angiographyMontefiore Medical CenterFirst-choice modalityNegative resultsVTE diagnosisPregnant patientsCohort studyNormal pregnancyPerfusion scanningPrimary outcomeInitial imagingPulmonary angiographyPerfusion scintigraphyUncommon diagnosisCT pulmonaryMedical CenterNegative studiesAppropriate Use Criteria for Ventilation-Perfusion Imaging in Pulmonary Embolism: Summary and Excerpts.
Waxman A, Bajc M, Brown M, Fahey F, Freeman L, Haramati L, Julien P, Le Gal G, Neilly B, Rabin J, Soudry G, Tapson V, Torbati S, Kauffman J, Ahuja S, Donohoe K. Appropriate Use Criteria for Ventilation-Perfusion Imaging in Pulmonary Embolism: Summary and Excerpts. Journal Of Nuclear Medicine 2017, 58: 13n-15n. PMID: 28461589.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
Retained Fibrin Sheaths
Krausz D, Fisher J, Rosen G, Haramati L, Jain V, Burton W, Godelman A, Levsky J, Taragin B, Cynamon J, Aviram G. Retained Fibrin Sheaths. Journal Of Thoracic Imaging 2014, 29: 118-124. PMID: 23846108, DOI: 10.1097/rti.0b013e318299ff22.Peer-Reviewed Original ResearchConceptsCentral venous cathetersFibrin sheathCVC removalVenous occlusionMultivariate analysisSheath remnantsCVC placementPatient agePulmonary embolismVenous cathetersCVC infectionVenous stenosisClinical associationsTomographic appearanceFemale sexBivariate analysisOcclusionSubstantial minorityCatheterPrevalenceCTWomenAgeSexCollaterals
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