2025
Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans
Hart T, Cui Y, Telford S, MarĂn-LĂłpez A, Calloway K, Dai Y, Matias J, DePonte K, Jaycox J, DeBlasio M, Hoornstra D, Belperron A, Cibichakravarthy B, Johnson E, Alameh M, Dwivedi G, Hovius J, Bockenstedt L, Weissman D, Ring A, Fikrig E. Tick feeding or vaccination with tick antigens elicits immunity to the Ixodes scapularis exoproteome in guinea pigs and humans. Science Translational Medicine 2025, 17: eads9207. PMID: 40138454, PMCID: PMC12067475, DOI: 10.1126/scitranslmed.ads9207.Peer-Reviewed Original ResearchConceptsTick antigensTick resistanceVector of tick-borne pathogensAcquired tick resistanceTick-borne pathogensIxodes scapularis</i>Tick feedingAntitick vaccinesDetectable antibody responseGuinea pigsTicksTick bitesAntigen cocktailPigsPrimary vectorFeedingAntibody responseHumoral responseImmunogen candidateAntigenLyme diseaseImmunoglobulin GRepeated exposureIxodesNorth America
2024
Combining short- and long-read sequencing unveils geographically structured diversity in Borrelia miyamotoi
Hoornstra D, Kuleshov K, Fingerle V, Hepner S, Wagemakers A, Strube C, Castillo-RamĂrez S, Bockenstedt L, Telford S, Sprong H, Platonov A, Margos G, Hovius J. Combining short- and long-read sequencing unveils geographically structured diversity in Borrelia miyamotoi. IScience 2024, 27: 110616. PMID: 39262806, PMCID: PMC11388275, DOI: 10.1016/j.isci.2024.110616.Peer-Reviewed Original ResearchComparative whole-genome sequencingCombination of IlluminaLong-read sequencingGenetically distinct populationsGenome assemblyPacBio platformPlasmid typesCore plasmidHuman pathogensGenetic basisDistinct populationsExpression sitesPlasmidGeographical originIxodes speciesGenomeIsolatesTick-borne human pathogenVector competenceStructural diversityNorth AmericaBorrelia miyamotoiPacBioIlluminaVirulence
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