Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons
Alexander T, Tymanskyj S, Kennedy K, Kaczmarek L, Covarrubias M. Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 122: e2411033121. PMID: 39739796, PMCID: PMC11725888, DOI: 10.1073/pnas.2411033121.Peer-Reviewed Original ResearchConceptsN-terminal inactivation domainDorsal root ganglionDorsal root ganglion neuronsSpike broadeningCumulative inactivationVoltage-gated K<sup>+</sup>Rat dorsal root ganglionViral vector approachPain modulationRoot ganglionGanglion neuronsKv3.4AP widthAction potentialsDynamic clampMechanosensory transductionInactivation domainNeuronsMolecular mechanismsFast recoveryInactivationSlow recoveryPhosphorylationPainRepolarization
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