2012
Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis
Scofield M, Korutla L, Jackson T, Kalivas P, Mackler S. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience 2012, 227: 44-54. PMID: 23022214, PMCID: PMC3505276, DOI: 10.1016/j.neuroscience.2012.09.043.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAspartic AcidCell DeathCholine O-AcetyltransferaseCytoplasmDNA-Binding ProteinsEmbryo, MammalianGene Expression RegulationGlial Fibrillary Acidic ProteinGlutamic AcidImmunoprecipitationNeoplasm ProteinsNeuronsPhosphopyruvate HydrataseProtein BindingRatsRepressor ProteinsSpinal CordTransfectionUbiquitinationConceptsNucleus accumbens-1Amyotrophic lateral sclerosisPOZ/BTB domainUbiquitin-proteasome systemTDP-43Protein 43Lateral sclerosisBTB domainPrimary spinal cord culturesDevelopment of ALSTAR DNA-binding protein 43POZ/BTB proteinDNA-binding protein 43Extracellular glutamate levelsTDP-43 expressionFull-length TDP-43Spinal cord culturesGST pulldown assaysPost-translational modificationsUbiquitinated protein aggregatesCholinergic neuronsGlutamate toxicityCord culturesGlutamate levelsSpinal cord
2007
NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines
Shen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, Klugmann M, Blendy J, Mackler S, Kalivas P. NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines. Journal Of Neuroscience 2007, 27: 8903-8913. PMID: 17699672, PMCID: PMC6672176, DOI: 10.1523/jneurosci.1571-07.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBicucullineCell Cycle ProteinsCells, CulturedCerebral CortexCullin ProteinsCysteine Proteinase InhibitorsDendritic SpinesEmbryo, MammalianGABA AntagonistsGreen Fluorescent ProteinsIntracellular Signaling Peptides and ProteinsLeupeptinsMiceMice, KnockoutNerve Tissue ProteinsNeuronsProteasome Endopeptidase ComplexProtein TransportRatsRepressor ProteinsRNA-Binding ProteinsTransfectionUbiquitinConceptsUbiquitin-proteasome systemDendritic spinesPostsynaptic densityProteolysis machineryProteasome complexTranscriptional proteinsProteasomeGene deletionSynaptic proteinsProteinCortical neuronsSynaptic remodelingSynaptic activitySynaptic plasticityBicucullinePotential missing linkRecruitmentSpineNeuronsNaC1Progressive accumulationMov34CullinMachineryProteolysis