2013
NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease
Korutla L, Furlong H, Mackler S. NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease. Neuroscience 2013, 257: 86-95. PMID: 24231739, DOI: 10.1016/j.neuroscience.2013.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnimalsBrainCell Line, TransformedCentral Nervous SystemCysteine Proteinase InhibitorsCytoplasmDown-RegulationGlutathione TransferaseHumansImmunoprecipitationLeupeptinsMaleMiceNerve Tissue ProteinsNeuronsParkinson DiseaseProteasome Endopeptidase ComplexRepressor ProteinsUbiquitin-Protein LigasesConceptsNucleus accumbens-1Neuronal cell deathParkinson's diseaseDisease patientsParkinson's disease patientsProteasomal activityPOZ/BTB proteinCell deathNeuronal cellsDiseaseParkin levelsProtein levelsCell susceptibilityParkin proteinProteasome protein levelsPatientsProteasome activityUbiquitin-dependent proteasome degradationCell viabilityParkin degradationDeathParkinKey proteinsProteasome degradationToxicity
2012
Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis
Scofield M, Korutla L, Jackson T, Kalivas P, Mackler S. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience 2012, 227: 44-54. PMID: 23022214, PMCID: PMC3505276, DOI: 10.1016/j.neuroscience.2012.09.043.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAspartic AcidCell DeathCholine O-AcetyltransferaseCytoplasmDNA-Binding ProteinsEmbryo, MammalianGene Expression RegulationGlial Fibrillary Acidic ProteinGlutamic AcidImmunoprecipitationNeoplasm ProteinsNeuronsPhosphopyruvate HydrataseProtein BindingRatsRepressor ProteinsSpinal CordTransfectionUbiquitinationConceptsNucleus accumbens-1Amyotrophic lateral sclerosisPOZ/BTB domainUbiquitin-proteasome systemTDP-43Protein 43Lateral sclerosisBTB domainPrimary spinal cord culturesDevelopment of ALSTAR DNA-binding protein 43POZ/BTB proteinDNA-binding protein 43Extracellular glutamate levelsTDP-43 expressionFull-length TDP-43Spinal cord culturesGST pulldown assaysPost-translational modificationsUbiquitinated protein aggregatesCholinergic neuronsGlutamate toxicityCord culturesGlutamate levelsSpinal cord
2007
NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoREST
Korutla L, Degnan R, Wang P, Mackler S. NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoREST. Journal Of Neurochemistry 2007, 101: 611-618. PMID: 17254023, DOI: 10.1111/j.1471-4159.2006.04387.x.Peer-Reviewed Original ResearchConceptsPOZ/BTB proteinPOZ/BTB domainBTB proteinsBTB domainProtein-protein interactionsHEK293T cellsNeuro-2a cellsT cellsTranscriptional regulatorsRepressor proteinRat brain samplesBrain samplesCoRESTCoimmunoprecipitation studiesHomodimer formationHomodimer assemblyRepressor mechanismProtein expressionProteinDirect interactionEndogenous interactionPresent studyPox virus
2005
The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal‐like cultures
Korutla L, Wang P, Mackler S. The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal‐like cultures. Journal Of Neurochemistry 2005, 94: 786-793. PMID: 16033423, DOI: 10.1111/j.1471-4159.2005.03206.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlotting, WesternButyratesCells, CulturedEnzyme InhibitorsGene Expression RegulationHippocampusHistone DeacetylasesHumansHydroxamic AcidsImmunoprecipitationMiceNerve Tissue ProteinsNeuroblastomaNeuronsPlasmidsProtein BindingProtein IsoformsRatsRepressor ProteinsTranscription, GeneticTransfectionTwo-Hybrid System TechniquesConceptsPOZ/BTB proteinProtein-protein interactionsBTB proteinsHistone deacetylasesPOZ domainTwo-hybridGlutathione S-transferase pulldownRecruit histone deacetylasesDifferent histone deacetylasesTranscriptional repressionGST pulldownSNAC1Histone deacetylase inhibitionCorepressorDeacetylasesRepressionDeacetylase inhibitionProteinPulldownHDAC-3NaC1MSin3ANucleus accumbensCNS regionsCoimmunoprecipitation