2013
NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease
Korutla L, Furlong H, Mackler S. NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease. Neuroscience 2013, 257: 86-95. PMID: 24231739, DOI: 10.1016/j.neuroscience.2013.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnimalsBrainCell Line, TransformedCentral Nervous SystemCysteine Proteinase InhibitorsCytoplasmDown-RegulationGlutathione TransferaseHumansImmunoprecipitationLeupeptinsMaleMiceNerve Tissue ProteinsNeuronsParkinson DiseaseProteasome Endopeptidase ComplexRepressor ProteinsUbiquitin-Protein LigasesConceptsNucleus accumbens-1Neuronal cell deathParkinson's diseaseDisease patientsParkinson's disease patientsProteasomal activityPOZ/BTB proteinCell deathNeuronal cellsDiseaseParkin levelsProtein levelsCell susceptibilityParkin proteinProteasome protein levelsPatientsProteasome activityUbiquitin-dependent proteasome degradationCell viabilityParkin degradationDeathParkinKey proteinsProteasome degradationToxicity
2007
NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines
Shen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, Klugmann M, Blendy J, Mackler S, Kalivas P. NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines. Journal Of Neuroscience 2007, 27: 8903-8913. PMID: 17699672, PMCID: PMC6672176, DOI: 10.1523/jneurosci.1571-07.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBicucullineCell Cycle ProteinsCells, CulturedCerebral CortexCullin ProteinsCysteine Proteinase InhibitorsDendritic SpinesEmbryo, MammalianGABA AntagonistsGreen Fluorescent ProteinsIntracellular Signaling Peptides and ProteinsLeupeptinsMiceMice, KnockoutNerve Tissue ProteinsNeuronsProteasome Endopeptidase ComplexProtein TransportRatsRepressor ProteinsRNA-Binding ProteinsTransfectionUbiquitinConceptsUbiquitin-proteasome systemDendritic spinesPostsynaptic densityProteolysis machineryProteasome complexTranscriptional proteinsProteasomeGene deletionSynaptic proteinsProteinCortical neuronsSynaptic remodelingSynaptic activitySynaptic plasticityBicucullinePotential missing linkRecruitmentSpineNeuronsNaC1Progressive accumulationMov34CullinMachineryProteolysis