1996
Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 Cells
Korutla L, Kumar R. Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 Cells. Biochemical And Biophysical Research Communications 1996, 220: 670-674. PMID: 8607823, DOI: 10.1006/bbrc.1996.0462.Peer-Reviewed Original ResearchConceptsEpidermal growth factorVesicular stomatitis virusInfectious viral particle productionAnti-EGF receptor monoclonal antibodyGrowth factorObserved antiviral effectReceptor monoclonal antibodyVesicular stomatitis virus replicationHuman epidermoid AVSV protein synthesisAntiviral effectViral particle productionAntiviral actionVSV infectionPrior treatmentViral protein synthesisVSV replicationPostinfection treatmentVirus replicationMonoclonal antibodiesInhibitory effectEarly effectsProtein synthesisSignificant inhibitionCell protectionMechanism of interferon action: in vivo activation of 91 kDa transcription factor.
Korutla L, Kumar R. Mechanism of interferon action: in vivo activation of 91 kDa transcription factor. Anticancer Research 1996, 16: 2789-95. PMID: 8917387.Peer-Reviewed Original ResearchConceptsLive human cellsHuman cellsSpecific cellular genesProtein tyrosine kinasesRegulation of expressionTreatment of cellsProtein phosphotyrosineCellular genesEarly biochemical eventsDistinct biological effectsTranscription factorsTyrosine phosphorylationTyrosine kinaseSodium orthovanadateBiochemical eventsCell growthInterferon actionBiological effectsPossible involvementCellsActivationVivo activationKinaseGenesPhosphorylation
1995
Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons
Kumar R, Korutla L. Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons. Experimental Cell Research 1995, 216: 143-148. PMID: 7529187, DOI: 10.1006/excr.1995.1018.Peer-Reviewed Original ResearchCell NucleusCytosolDNA-Binding ProteinsGene Expression RegulationHumansInterferon Type IInterferon-gammaInterferon-Stimulated Gene Factor 3Interferon-Stimulated Gene Factor 3, gamma SubunitKineticsPhosphorylationPhosphotyrosineRecombinant ProteinsRNA, MessengerTranscription FactorsTumor Cells, CulturedTyrosineGrowth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways.
Kumar R, Korutla L. Growth inhibition of human acute promyelocytic leukemia NB-4 cells by interferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways. Anticancer Research 1995, 15: 353-60. PMID: 7763006.Peer-Reviewed Original Research
1994
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells
Korutla L, Kumar R. Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells. Biochimica Et Biophysica Acta 1994, 1224: 597-600. PMID: 7803521, DOI: 10.1016/0167-4889(94)90299-2.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCell DivisionCurcuminErbB ReceptorsHumansPhosphorylationTumor Cells, CulturedConceptsReceptor's intrinsic kinase activityShort-term treatmentObserved early effectsTime-dependent mannerA431 cellsReceptor kinase activityKinase activityInhibitory effectEarly effectsAntigrowth actionEGF-induced tyrosine phosphorylationEpidermoid carcinoma A431 cellsHuman epidermoid carcinoma A431 cellsIntrinsic kinase activityEpidermal growth factor receptor kinase activityEGF receptorCurcuminCell growthCellsTyrosine phosphorylationDoseCell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells.
Kumar R, Korutla L, Zhang K. Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells. Journal Of Biological Chemistry 1994, 269: 25437-25441. PMID: 7929242, DOI: 10.1016/s0021-9258(18)47269-9.Peer-Reviewed Original ResearchMeSH Keywords2',5'-Oligoadenylate SynthetaseBase SequenceBurkitt LymphomaCell CycleDNA-Binding ProteinsEnzyme ActivationG1 PhaseGene Expression RegulationHumansInterferon-alphaJanus Kinase 1Molecular Sequence DataProtein-Tyrosine KinasesProteinsS PhaseSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTumor Cells, CulturedTYK2 KinaseConceptsTyk-2 kinaseJAK-1Synthetase proteinTyrosine phosphorylationGene expressionCell cycle-dependent modulationCell cycleCell cycle-dependent expressionCell cycle-dependent changesInducible gene expressionGene factor 3Unique expression patternCycle-dependent expressionG1/S phaseCell cycle progressionG1/SIFN-inducible gene expressionG2/M.Human Burkitt lymphoma Daudi cellsInduction of expressionG1/S blockG2/MDaudi cellsIFN-alpha-inducible genesCycle-dependent changes