Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Levine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.Peer-Reviewed Original ResearchConceptsSyncytin-1Preeclampsia groupMaternal circulationExtracellular vesiclesCommon placental pathologyHigh expressionDiagnosis of preeclampsiaConditions of preeclampsiaBone alkaline phosphatasePotential physiologic roleTissue-specific biomarkersExtracellular microvesiclesPlasma extracellular vesiclesAlkaline phosphatasePreeclampsia subjectsNormal pregnancyPlacental pathologyCell extracellular vesiclesImproved biomarkersMaternal bloodPreeclampsiaPlacental syncytiotrophoblastMaternal plasmaPlacental alkaline phosphatasePhysiologic role