Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin
Korutla L, Cheung J, Medelsohn J, Kumar R. Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin. Carcinogenesis 1995, 16: 1741-1745. PMID: 7634398, DOI: 10.1093/carcin/16.8.1741.Peer-Reviewed Original ResearchConceptsGrowth stimulatory pathwaysTumor cell growthTime-dependent mannerAnti-proliferative strategyTyrosine phosphorylationEpidermal growth factorEpidermal growth factor receptor tyrosine phosphorylationCurcumin treatmentActivation of EGFCalcium releaseStimulatory pathwayReceptor tyrosine phosphorylationTreatment of cellsEGF receptor phosphorylationKinase inhibitorsGrowth factorSurface expressionReceptor phosphorylationHuman EGFCurcuminEGFInhibition of EGFPotent inhibitorActivationCell growth