2015
Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms
Botsios S, Tittman S, Manuelidis L. Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms. Virulence 2015, 6: 787-801. PMID: 26556670, PMCID: PMC4826107, DOI: 10.1080/21505594.2015.1098804.Peer-Reviewed Original ResearchConceptsInfectious titerInnate immune responseHuman CJDResistant virusesIatrogenic infectionGT1 cellsBrain changesImmune responseInfectious agentsTSE agentsScrapie agentCJDPrion protein amyloidSheep scrapieVirulent microbesInfectious particlesMin exposureIntrinsic resistanceTreatmentTitersPrP amyloidScrapieAmyloidCultured cellsDeep proteomic analysis
2010
Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell‐to‐cell contacts
Miyazawa K, Emmerling K, Manuelidis L. Proliferative arrest of neural cells induces prion protein synthesis, nanotube formation, and cell‐to‐cell contacts. Journal Of Cellular Biochemistry 2010, 111: 239-247. PMID: 20518071, PMCID: PMC2930104, DOI: 10.1002/jcb.22723.Peer-Reviewed Original ResearchConceptsProliferative arrestTerminal differentiationCell division arrestT antigenStationary cellsNeuronal precursor cellsDivision arrestHost prion proteinKey developmental timesSV-40 T antigenAdherent junctionsDevelopmental timeProtein synthesisLiving cellsMRNA transcriptsPrion proteinNeural cellsPrecursor cellsCell contactGrowth conesDNA-synthesizing cellsCellsReduced serumNeuritic processesDifferentiation
2009
The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt–Jakob disease and scrapie agents
Manuelidis L, Chakrabarty T, Miyazawa K, Nduom NA, Emmerling K. The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt–Jakob disease and scrapie agents. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 13529-13534. PMID: 19633190, PMCID: PMC2715327, DOI: 10.1073/pnas.0905825106.Peer-Reviewed Original ResearchConceptsSporadic Creutzfeldt-Jakob diseaseCreutzfeldt-Jakob diseaseBovine spongiform encephalopathyBSE agentHuman sporadic Creutzfeldt-Jakob diseaseInfectious agentsEpidemic bovine spongiform encephalopathyTSE agentsScrapie agentTransmissible spongiform encephalopathy agentsSpongiform encephalopathy agentKuru agentLymphoreticular involvementBrain neuropathologySporadic CJDGT1 cellsNormal miceInfected humansNeurodegenerative diseasesDiseaseViral receptorsInfectious neurodegenerative diseasesSheep scrapieSpongiform encephalopathiesHigh levels
1988
Movement of the X Chromosome in Epilepsy
Borden J, Manuelidis L. Movement of the X Chromosome in Epilepsy. Science 1988, 242: 1687-1691. PMID: 3201257, DOI: 10.1126/science.3201257.Peer-Reviewed Original Research