2019
Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration
Szigeti‐Buck K, Manuelidis L. Prokaryotic SPHINX replication sequences are conserved in mammalian brain and participate in neurodegeneration. Journal Of Cellular Biochemistry 2019, 120: 17687-17698. PMID: 31231867, DOI: 10.1002/jcb.29035.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseGuinea pigsMammalian brainSporadic Creutzfeldt-Jakob diseaseOnly excitatory neuronsHippocampal pyramidal neuronsGranule cell layerInternal granule cell layerPancreatic islet cellsPyramidal neuronsSporadic CJDHidden infectionType synapsesExcitatory synapsesExcitatory neuronsMossy fibersPurkinje neuronsProgressive neurodegenerationNeuron synapsesIslet cellsSpecific neuronsWestern blotNeuronsPancreatic exocrine cellsKidney tubules
1983
Scrapie-associated fibrils in Creutzfeldt–Jakob disease
Merz P, Somerville R, Wisniewski H, Manuelidis L, Manuelidis E. Scrapie-associated fibrils in Creutzfeldt–Jakob disease. Nature 1983, 306: 474-476. PMID: 6358899, DOI: 10.1038/306474a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCreutzfeldt-Jakob SyndromeCricetinaeGuinea PigsHumansMiceScrapieSheepSpleenConceptsScrapie associated fibrilsCreutzfeldt-Jakob diseaseCentral nervous systemTitre of infectivityScrapie of sheepInfected brainPathological responseProgressive degenerationNervous systemSynaptosomal preparationsInfectious agentsBrain fractionsTransmissible encephalopathiesDiseaseHuman casesSpleen extractsAbnormal fibrilsSusceptible hostsScrapieClose associationDifferent tissuesEncephalopathyAgentsDegenerationTitres
1978
TRANSMISSION, FROM MAN TO HAMSTER, OF CREUTZFELDT-JAKOB DISEASE WITH CLINICAL RECOVERY
Manuelidis E, Manuelidis L, Pincus J, Collins W. TRANSMISSION, FROM MAN TO HAMSTER, OF CREUTZFELDT-JAKOB DISEASE WITH CLINICAL RECOVERY. The Lancet 1978, 312: 40-42. PMID: 78232, DOI: 10.1016/s0140-6736(78)91345-4.Peer-Reviewed Original Research
1976
Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.
Manuelidis E, Kim J, Angelo J, Manuelidis L. Serial propagation of Creutzfeldt-Jakob disease in guinea pigs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1976, 73: 223-227. PMID: 1108016, PMCID: PMC335873, DOI: 10.1073/pnas.73.1.223.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCreutzfeldt-Jakob SyndromeDisease Models, AnimalGuinea PigsHumansHydrocephalusThalamusVisual CortexConceptsCreutzfeldt-Jakob diseaseGuinea pigsSubacute spongiform virus encephalopathiesSpongiform virus encephalopathiesHydrocephalus ex vacuoSubcortical gray structuresSerial propagationPercent takeNeuronal destructionCerebral atrophyNeuronal lossCerebral cortexEx vacuoGray structuresDiseaseSubsequent passagesPigsMorbidityAtrophyEncephalopathyIncubation periodInfectionMortalityCortexSymptomatology