Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.
Manuelidis E, Kim J, Angelo J, Manuelidis L. Serial propagation of Creutzfeldt-Jakob disease in guinea pigs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1976, 73: 223-227. PMID: 1108016, PMCID: PMC335873, DOI: 10.1073/pnas.73.1.223.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseGuinea pigsSubacute spongiform virus encephalopathiesSpongiform virus encephalopathiesHydrocephalus ex vacuoSubcortical gray structuresSerial propagationPercent takeNeuronal destructionCerebral atrophyNeuronal lossCerebral cortexEx vacuoGray structuresDiseaseSubsequent passagesPigsMorbidityAtrophyEncephalopathyIncubation periodInfectionMortalityCortexSymptomatology