2024
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, Daskalakis N, Duncan L, Polimanti R, Aaronson C, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegoviç E, Babić D, Bacanu S, Baker D, Batzler A, Beckham J, Belangero S, Benjet C, Bergner C, Bierer L, Biernacka J, Bierut L, Bisson J, Boks M, Bolger E, Brandolino A, Breen G, Bressan R, Bryant R, Bustamante A, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum A, Børte S, Cahn L, Calabrese J, Caldas-de-Almeida J, Chatzinakos C, Cheema S, Clouston S, Colodro-Conde L, Coombes B, Cruz-Fuentes C, Dale A, Dalvie S, Davis L, Deckert J, Delahanty D, Dennis M, Desarnaud F, DiPietro C, Disner S, Docherty A, Domschke K, Dyb G, Kulenović A, Edenberg H, Evans A, Fabbri C, Fani N, Farrer L, Feder A, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gelaye B, Gelernter J, Geuze E, Gillespie C, Goleva S, Gordon S, Goçi A, Grasser L, Guindalini C, Haas M, Hagenaars S, Hauser M, Heath A, Hemmings S, Hesselbrock V, Hickie I, Hogan K, Hougaard D, Huang H, Huckins L, Hveem K, Jakovljević M, Javanbakht A, Jenkins G, Johnson J, Jones I, Jovanovic T, Karstoft K, Kaufman M, Kennedy J, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kotov R, Kranzler H, Krebs K, Kremen W, Kuan P, Lawford B, Lebois L, Lehto K, Levey D, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lu Y, Luft B, Lupton M, Luykx J, Makotkine I, Maples-Keller J, Marchese S, Marmar C, Martin N, MartĂnez-Levy G, McAloney K, McFarlane A, McLaughlin K, McLean S, Medland S, Mehta D, Meyers J, Michopoulos V, Mikita E, Milani L, Milberg W, Miller M, Morey R, Morris C, Mors O, Mortensen P, Mufford M, Nelson E, Nordentoft M, Norman S, Nugent N, O’Donnell M, Orcutt H, Pan P, Panizzon M, Pathak G, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Porjesz B, Powers A, Qin X, Ratanatharathorn A, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Runz H, Rutten B, de Viteri S, Salum G, Sampson L, Sanchez S, Santoro M, Seah C, Seedat S, Seng J, Shabalin A, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stensland S, Stevens J, Sumner J, Teicher M, Thompson W, Tiwari A, Trapido E, Uddin M, Ursano R, ValdimarsdĂłttir U, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt F, Werge T, Williams M, Williamson D, Winsvold B, Winternitz S, Wolf C, Wolf E, Xia Y, Xiong Y, Yehuda R, Young K, Young R, Zai C, Zai G, Zervas M, Zhao H, Zoellner L, Zwart J, deRoon-Cassini T, van Rooij S, van den Heuvel L, Stein M, Ressler K, Koenen K. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. Nature Genetics 2024, 56: 792-808. PMID: 38637617, PMCID: PMC11396662, DOI: 10.1038/s41588-024-01707-9.Peer-Reviewed Original ResearchConceptsMeta-analysis of genome-wide association studiesGenome-wide significant lociMulti-ancestry meta-analysisGenome-wide association analysisGenome-wide association studiesIndividuals of European ancestryPotential causal genesNative American ancestryMulti-omics approachPost-traumatic stress disorderAdmixed individualsSignificant lociRisk lociCausal genesAssociation studiesAssociation analysisFunctional genesTranscription factorsGenetic studiesAmerican ancestryEuropean ancestryAxon guidanceSynaptic structureLociGenes
2022
EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS
Kozik E, Kowalchyk M, Brinkman H, Desarnaud F, Yehuda R, Pietrzak R, Huckins L, Feder A. EPIGENOME-WIDE PREDICTORS OF RESPONSE TO INTERNET-BASED COGNITIVE-BEHAVIORAL THERAPY FOR PTSD IN WORLD TRADE CENTER TRAUMA SURVIVORS. European Neuropsychopharmacology 2022, 63: e130. DOI: 10.1016/j.euroneuro.2022.07.242.Peer-Reviewed Original Research
2021
Internet-based cognitive behavioral therapy versus internet-based modified present-centered therapy for world trade center responders and survivors with posttraumatic stress disorder: rationale and design of a randomized controlled trial
Brinkman H, Kowalchyk M, Cahn L, Aaronson C, Böttche M, Presseau C, Markowitz J, Litz B, Huckins L, Yehuda R, Knaevelsrud C, Pietrzak R, Feder A. Internet-based cognitive behavioral therapy versus internet-based modified present-centered therapy for world trade center responders and survivors with posttraumatic stress disorder: rationale and design of a randomized controlled trial. International Journal Of Clinical Trials 2021, 8: 202-210. DOI: 10.18203/2349-3259.ijct20212843.Peer-Reviewed Original ResearchInternet-based cognitive behavioral therapyCognitive behavioral therapyBehavioral therapyActive comparison treatmentsWorld Trade Center respondersPosttraumatic stress disorder (PTSD) symptomsEvidence-based treatmentsDesign of trialsQuality of lifeTrauma-affected populationsPost-traumatic growthPosttraumatic stress disorderWTC rescueThird variable explanationsActive treatmentWTC workersComorbid depressiveWTC respondersTreatment responseCBT trialsCBT interventionTherapyPTSD symptomsRecovery workersCBT studies
2020
Genetic Regulation of PTSD and Resilience Among World Trade Center Responders
Huckins L, Pietrzak R, Yehuda R, Stahl E, Feder A. Genetic Regulation of PTSD and Resilience Among World Trade Center Responders. Biological Psychiatry 2020, 87: s26. DOI: 10.1016/j.biopsych.2020.02.091.Peer-Reviewed Original Research
2019
S16GENETIC REGULATION OF PTSD AND RESILIENCE AMONG WORLD TRADE CENTER RESPONDERS
Huckins L, Yehuda R, Pietrzak R, Stahl E, Feder A. S16GENETIC REGULATION OF PTSD AND RESILIENCE AMONG WORLD TRADE CENTER RESPONDERS. European Neuropsychopharmacology 2019, 29: s121-s122. DOI: 10.1016/j.euroneuro.2019.08.017.Peer-Reviewed Original Research
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