2025
Implications of gene Ă— environment interactions in post-traumatic stress disorder risk and treatment
Seah C, Sidamon-Eristoff A, Huckins L, Brennand K. Implications of gene Ă— environment interactions in post-traumatic stress disorder risk and treatment. Journal Of Clinical Investigation 2025, 135: e185102. PMID: 40026250, PMCID: PMC11870735, DOI: 10.1172/jci185102.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderGene x environment interactionsGenetic component of riskLimitations of genetic studiesTreating post-traumatic stress disorderExposure to traumatic stressPost-traumatic stress disorder riskInteraction of traumaGenetic screeningGenetic studiesGenetic componentEnvironment interactionMolecular mechanismsStress disorderPTSD riskTraumatic exposureTraumatic stressTraumatic experiencesDisorder riskGenetic factorsNovel therapeuticsBiological mechanismsGWASGeneral populationGenes
2019
SU11 GENETICALLY PREDICTED GENE EXPRESSION IN THE BRAIN AND PERIPHERAL TISSUES ASSOCIATES WITH PTSD
Huckins L, Girdhar K, Dobbyn A, Jovanovic T, Nievergelt C, Hoffman G, Maihofer A, Stein M, Sklar P, Ressler K, Buxbaum J, Stahl E, Daskalakis N, Consortium T, Group P. SU11 GENETICALLY PREDICTED GENE EXPRESSION IN THE BRAIN AND PERIPHERAL TISSUES ASSOCIATES WITH PTSD. European Neuropsychopharmacology 2019, 29: s892-s893. DOI: 10.1016/j.euroneuro.2017.08.200.Peer-Reviewed Original ResearchPost-traumatic stress disorderPsychiatric disordersBrain regionsPost-traumatic stress disorder patientsPost-traumatic stress disorder developmentGenotype-Tissue ExpressionCommonMind ConsortiumIndividuals exposed to traumaDebilitating psychiatric disorderPeripheral tissuesGene expression prediction modelsGene expressionGene-tissue associationsPGC-PTSDStress disorderPTSD riskExpression prediction modelsTrauma typesMulti-system dysregulationImmune dysregulationGenotype dataDisordersGene associationsReference panelGenetic heterogeneity
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