2024
P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study
Lehto J, Aarnio R, Tuisku J, Sucksdorff M, Koivumäki E, Nylund M, Helin S, Rajander J, Danon J, Gilchrist J, Kassiou M, Oikonen V, Airas L. P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study. EJNMMI Research 2024, 14: 123. PMID: 39636350, PMCID: PMC11621262, DOI: 10.1186/s13550-024-01186-3.Peer-Reviewed Original ResearchPerilesional rimTracer bindingDisability progressionMS patientsMS brainsLesion rimWhite matterProgressive MS patientsPro-inflammatory microgliaRelapsed patientsSmoldering inflammationT1 lesionsMales compared to femalesNew-onsetProgressive patientsTracer uptakeParent tracerP2XDisease durationProgressive MSHealthy controlsPatientsPET studiesPerilesional areaFree fraction
2018
Natalizumab Treatment of Multiple Sclerosis Leads to Diminished Microglial Activation in the Normal Appearing White Matter (P3.390)
Airas L, Sucksdorff M, Tuisku J, Rissanen E. Natalizumab Treatment of Multiple Sclerosis Leads to Diminished Microglial Activation in the Normal Appearing White Matter (P3.390). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p3.390.Peer-Reviewed Original Research
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