Smouldering‐Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions
Scalfari A, Traboulsee A, Oh J, Airas L, Bittner S, Calabrese M, Dominguez J, Granziera C, Greenberg B, Hellwig K, Illes Z, Lycke J, Popescu V, Bagnato F, Giovannoni G. Smouldering‐Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions. Annals Of Neurology 2024, 96: 826-845. PMID: 39051525, DOI: 10.1002/ana.27034.Peer-Reviewed Original ResearchMultiple sclerosisProgression independent of relapse activityCognitive symptomsIndependent of relapse activitySuppression of relapseInternational consensus statementClinical implicationsRelapse activityTherapeutic suppressionClinical trialsConsensus statementFuture directionsTherapeutic targetRoutine practicePathological substrateProgressive independencePathological processes
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