2012
Structure–function associations in hippocampus in bipolar disorder
Chepenik LG, Wang F, Spencer L, Spann M, Kalmar JH, Womer F, Edmiston E, Pittman B, Blumberg HP. Structure–function associations in hippocampus in bipolar disorder. Biological Psychology 2012, 90: 18-22. PMID: 22342942, PMCID: PMC3319637, DOI: 10.1016/j.biopsycho.2012.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceBipolar DisorderFemaleHippocampusHumansMagnetic Resonance ImagingMaleMemoryMemory DisordersMiddle AgedNeuropsychological TestsOrgan SizeVerbal LearningConceptsSmaller hippocampus volumesBipolar disorderHippocampus volumeMemory deficitsCalifornia Verbal Learning Test-Second EditionImpaired performanceHealthy comparison subjectsVerbal memory impairmentVerbal memory functionVerbal memory deficitsAntidepressant medicationStructure-function associationsBD subjectsBD groupHC groupComparison subjectsHippocampus structureMemory impairmentPotential associationMagnetic resonance imagesImproved memoryMemory functionResonance imagesSubjectsDeficits
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes