2025
Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?
Erden M, Oktay K. Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles? Human Reproduction 2025, deaf024. PMID: 39986689, DOI: 10.1093/humrep/deaf024.Peer-Reviewed Original ResearchPrimordial follicle activationFollicle activationGonadotoxic chemotherapyOvarian reserveOvarian primordial follicle reserveActivation of primordial folliclesOvarian reserve depletionPrimordial follicle depletionPrimordial follicle reserveChemotherapy-induced damageFollicle reservePrimordial folliclesChemotherapy exposureFollicle depletionFollicle deathFertility preservationPharmacological optionsChemotherapyApoptotic deathBradford Hill criteriaDNA double-strand breaksFolliclesMolecular mechanismsDouble-strand breaksDeath
2024
Female Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
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