2025
P-396 Improving post-ovarian transplant primordial follicle survival by neovascularizing approaches
Celik S, Erden M, Rho N, Molla W, Oktay K. P-396 Improving post-ovarian transplant primordial follicle survival by neovascularizing approaches. Human Reproduction 2025, 40: deaf097.702. DOI: 10.1093/humrep/deaf097.702.Peer-Reviewed Original ResearchPrimordial follicle lossPrimordial follicle densityFollicle lossSphingosine-1-phosphateFlexHD PliableFTY-720Follicle activationOvarian graftsPrimordial folliclesLoss of primordial folliclesSevere-combined-immunodeficient miceFollicle densitySevere-combined-immunodeficiencyOvarian tissue transplantationPrimordial follicle activationPrimordial follicle survivalOvarian cortical piecesAcellular dermal matrixParaffin-embedded tissuesFollicle survivalCortical piecesChorion allograftTransplant outcomesCadaveric organ donorsWIDER IMPLICATIONS
2024
Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation
Johnson J, Lawley S, Emerson J, Oktay K. Modeling delay of age at natural menopause with planned tissue cryopreservation and autologous transplantation. American Journal Of Obstetrics And Gynecology 2024, 230: 426.e1-426.e8. PMID: 38184290, PMCID: PMC11625473, DOI: 10.1016/j.ajog.2023.12.037.Peer-Reviewed Original ResearchOvarian tissue cryopreservationTissue cryopreservationFollicle survivalOvarian reserveOvarian agingOvarian cortexOvarian tissue freezingDelay of ageEarly adult agePost transplantationGonadotoxic treatmentHealthy womenFollicle lossNatural menopauseAutologous transplantationMenopauseMost womenTransplantationOvarian tissueCortex removalTransplant techniquesMultiple proceduresAge 25Adult ageTissue harvest
2021
Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezing
2017
Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage
Kawahara T, Sugishita Y, Taylan E, Suzuki N, Moy F, Oktay K. Vitrification versus slow freezing of human ovarian tissue: a comparison of follicle survival and DNA damage. Fertility And Sterility 2017, 108: e56-e57. DOI: 10.1016/j.fertnstert.2017.07.179.Peer-Reviewed Original Research
2011
Sphingosine-1-phosphate accelerates neoangiogenesis, reduces hypoxia, and improves primordial follicle survival in human ovarian xenografts: a prelude to improving ovarian transplantation outcomes
Soleimani R, Heytens E, Oktay K. Sphingosine-1-phosphate accelerates neoangiogenesis, reduces hypoxia, and improves primordial follicle survival in human ovarian xenografts: a prelude to improving ovarian transplantation outcomes. Fertility And Sterility 2011, 96: s34. DOI: 10.1016/j.fertnstert.2011.07.138.Peer-Reviewed Original Research
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