2025
Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?
Erden M, Oktay K. Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles? Human Reproduction 2025, deaf024. PMID: 39986689, DOI: 10.1093/humrep/deaf024.Peer-Reviewed Original ResearchPrimordial follicle activationFollicle activationGonadotoxic chemotherapyOvarian reserveOvarian primordial follicle reserveActivation of primordial folliclesOvarian reserve depletionPrimordial follicle depletionPrimordial follicle reserveChemotherapy-induced damageFollicle reservePrimordial folliclesChemotherapy exposureFollicle depletionFollicle deathFertility preservationPharmacological optionsChemotherapyApoptotic deathBradford Hill criteriaDNA double-strand breaksFolliclesMolecular mechanismsDouble-strand breaksDeath
2019
Chemotherapy causes primordial follicle death in the human ovary via multiple apoptotic pathways and not by “burn out”
Titus S, Oktay K. Chemotherapy causes primordial follicle death in the human ovary via multiple apoptotic pathways and not by “burn out”. Fertility And Sterility 2019, 112: e84. DOI: 10.1016/j.fertnstert.2019.07.340.Peer-Reviewed Original Research
2012
Sphingosine-1-phosphate prevents human primordial follicle death induced by a diverse set of chemotherapy agents
Li F, Akula K, Ozkaya E, De Sutter P, Oktay K. Sphingosine-1-phosphate prevents human primordial follicle death induced by a diverse set of chemotherapy agents. Fertility And Sterility 2012, 98: s69. DOI: 10.1016/j.fertnstert.2012.07.247.Peer-Reviewed Original ResearchFollicle deathChemotherapy agentsPrevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease
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