2025
Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?
Erden M, Oktay K. Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles? Human Reproduction 2025, deaf024. PMID: 39986689, DOI: 10.1093/humrep/deaf024.Peer-Reviewed Original ResearchPrimordial follicle activationFollicle activationGonadotoxic chemotherapyOvarian reserveOvarian primordial follicle reserveActivation of primordial folliclesOvarian reserve depletionPrimordial follicle depletionPrimordial follicle reserveChemotherapy-induced damageFollicle reservePrimordial folliclesChemotherapy exposureFollicle depletionFollicle deathFertility preservationPharmacological optionsChemotherapyApoptotic deathBradford Hill criteriaDNA double-strand breaksFolliclesMolecular mechanismsDouble-strand breaksDeath
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2012
Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate
LI F, Ozkaya E, Akula K, Desutter P, Oktay K. Prevention of chemotherapy-induced damage to ovarian reserve by sphingosine-1-phosphate. Journal Of Clinical Oncology 2012, 30: 1097-1097. DOI: 10.1200/jco.2012.30.15_suppl.1097.Peer-Reviewed Original ResearchFollicle deathOvarian functionApoptotic folliclesOvarian reserveChemotherapy agentsPrimordial folliclesMini-osmotic pumpsOld NOD miceChemotherapy-induced damageAssisted reproduction techniquesSphingosine-1-PhosphateChemotherapy injectionsNOD miceContinuous infusionTotal folliclesPharmacological meansD groupS1P treatmentMouse ovariesPathway inhibitorCytotoxic agentsFolliclesS1PDeathSignificant decrease
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply