2025
Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?
Erden M, Oktay K. Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles? Human Reproduction 2025, deaf024. PMID: 39986689, DOI: 10.1093/humrep/deaf024.Peer-Reviewed Original ResearchPrimordial follicle activationFollicle activationGonadotoxic chemotherapyOvarian reserveOvarian primordial follicle reserveActivation of primordial folliclesOvarian reserve depletionPrimordial follicle depletionPrimordial follicle reserveChemotherapy-induced damageFollicle reservePrimordial folliclesChemotherapy exposureFollicle depletionFollicle deathFertility preservationPharmacological optionsChemotherapyApoptotic deathBradford Hill criteriaDNA double-strand breaksFolliclesMolecular mechanismsDouble-strand breaksDeath
2024
The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging
Suzuki R, Tan X, Szymanska K, Kubikova N, Perez C, Wells D, Oktay K. The role of declining ataxia-telangiectasia-mutated (ATM) function in oocyte aging. Cell Death Discovery 2024, 10: 302. PMID: 38914566, PMCID: PMC11196715, DOI: 10.1038/s41420-024-02041-z.Peer-Reviewed Original ResearchOocyte qualityAtaxia telangiectasia-mutatedOocyte agingMaintenance of oocyte qualityDNA double-strand breaksMeiosis in vitroPoor embryo developmentImpaired oocyte qualityATM functionMolecular cytogenetic analysisFormation of DNA DSBsDeath compared to controlsBlastocyst stageEmbryo cleavageDNA DSBsOvarian agingCytogenetic analysisResistance to genotoxic stressActive metaboliteNext-generation sequencingRates compared to controlsIn vitro cultureOocytesDNA DSB repairAge-induced declineFemale Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
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