2025
Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis
Turan V, Oktem O, Bang H, Oktay K. Utilization and fertility preservation outcomes in women undergoing embryo cryopreservation before breast cancer treatment: a meta-analysis. Clinical Breast Cancer 2025 DOI: 10.1016/j.clbc.2025.06.003.Peer-Reviewed Original ResearchBreast cancer treatmentFertility preservation rateLive birth rateClinical pregnancyCancer treatmentFertility preservationEmbryo transferPreservation rateBirth rateFertility preservation outcomesFrozen embryo transferCochrane Library databasesRandom-effects modelSecondary outcome measuresPregnancy outcomesEmbryo cryopreservationBreast cancerPreservation outcomesLibrary databasesPregnancyBreastMeta-analysisOutcome measuresWomenTreatmentDevelopments in pharmacotherapy for the preservation of ovarian function during cancer treatment
Turan V, Oktay K. Developments in pharmacotherapy for the preservation of ovarian function during cancer treatment. Expert Opinion On Pharmacotherapy 2025, 26: 897-907. PMID: 40271805, DOI: 10.1080/14656566.2025.2495090.Peer-Reviewed Original ResearchConceptsOvarian functionPharmacological therapyPreservation of ovarian functionChemotherapy-induced ovarian damageCancer treatmentOvarian cortex cryopreservationProtect ovarian functionPremature ovarian failureHuman ovarian tissueDevelopment of pharmacological therapiesChemotherapy-induced damageFertility preservation proceduresTargeted pharmacological therapiesAnti-cancer therapyOvarian failureHuman ovaryOocyte apoptosisOvarian damageOvarian reservePreserving fertilityOvarian stromaChemotherapy typeChemotherapeutic agentsProtect ovariesOvarian tissue
2024
Female Fertility Preservation for Oncological Reasons
Erden M, Oktay K. Female Fertility Preservation for Oncological Reasons. 2024 DOI: 10.1016/b978-0-443-21477-6.00277-7.Peer-Reviewed Original ResearchGonadotoxic chemotherapyPrimordial folliclesOvarian tissue cryopreservationFertility preservation techniquesFemale fertility preservationFertility preservation interventionFertility preservation optionsEnhanced DNA repairPelvic radiotherapyOvarian suppressionRadical surgeryOvarian insufficiencyTissue cryopreservationOncological reasonsOvarian damageFertility preservationPharmacological optionsPharmacological agentsPre-treatment preparationPreservation optionsCancer treatmentApoptotic deathBiological parenthoodChemotherapyDNA double-strand breaks
2015
Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment
Turan V, Oktay K. Chapter 4 The Current Understanding of Clinical Data on Ovarian Toxicity from Cancer Treatment. 2015, 47-61. DOI: 10.1016/b978-0-12-801591-9.00004-7.Peer-Reviewed Original ResearchCancer treatmentComplications of chemotherapySystemic lupus erythematosusPremature ovarian insufficiencyQuality of lifeOvarian damageLupus erythematosusOvarian toxicityAutoimmune diseasesOvarian functionBRCA mutationsReproductive ageRelative riskChemotherapy agentsClinical dataOvarian insufficiencySurvival rateChemotherapeutic agentsOvarian cellsChemotherapyHuman dataTreatmentCurrent understandingErythematosusComplications
2011
Approach to Fertility Preservation in Adult and Prepubertal Females
Rodriguez-Wallberg K, Oktay K. Approach to Fertility Preservation in Adult and Prepubertal Females. 2011, 233-241. DOI: 10.1007/978-1-4419-1783-6_18.Peer-Reviewed Original ResearchFertility preservationFemale patientsCancer treatmentFemale cancer survivorsAdult female patientsClinical presentationGonadotoxic treatmentCancer survivorsPrepubertal girlsPsychosocial distressPrepubertal femalesPatientsOvarian tissueMost cancersAvailable evidenceInfertilityMain diseaseTreatmentCancerWestern countriesAgeOnly optionOptionsIncidenceDisease
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomen
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