Krishna C. Mudumbi, PhD

Krishna is interested in exploring the kinetics of receptor tyrosine kinase (RTK) signaling through the use of biophysical techniques, with a focus on single-molecule microscopy. He gained experience in single-molecule microscopy during his Ph.D. work in the lab of Weidong Yang at Temple University studying nuclear envelope membrane proteins. During his time there, he studied the translocation of nuclear envelope transmembrane proteins into the nucleus, as well as developed a single-molecule FRAP technique to study the distribution of transmembrane proteins on the nuclear envelope.

In Mark Lemmon's lab, Krishna is using his expertise with single-molecule microscopy to understand how the dynamics of EGFR dimerization contribute to its signaling. Using single-particle tracking, his work recently revealed how the different domains of EGFR contribute to its dimerization and oligomerization on the cell surface. He continues to use advanced imaging techniques, cellular, and biochemical assays to explore how the kinetics and spatial organization of EGFR on the plasma membrane defines signaling specificity.