2025
Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction.
Gusdorf J, Faridi K, Wang T, Mena-Hurtado C, Smolderen K, Rymer J, Curtis J, Li S, Secemsky E. Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2025, 14: e040526. PMID: 40497502, DOI: 10.1161/jaha.124.040526.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction typesPeripheral arterial diseaseAcute myocardial infarctionIn-hospital mortalityPeripheral artery disease hospitalizationsIn-hospital outcomesAcute myocardial infarction hospitalizationsCardiac arrestHigh-risk populationAssociated with increased ratesLong-term riskRevascularized patientsInpatient outcomesMultivariable adjustmentHeart failureArtery diseasePrimary outcomeAdverse cardiovascular outcomesUS sitesHeightened riskAge groupsSecondary end pointsSubgroup analysisDialysis initiationCoronary artery diseaseImpact of Sudden Cardiac Arrest and Implantable Cardiac Defibrillator Shocks on Mental Health Review and Management Guidance
Torbey E, Mena-Hurtado C, Jackson J, Samaan Z, Sears S, Pedersen S, Lala A, Thachil R, Steiner J, Ilonze O, Jones D, Watson K, Price A, Knoepke C, Cheung J, Smolderen K, Group A. Impact of Sudden Cardiac Arrest and Implantable Cardiac Defibrillator Shocks on Mental Health Review and Management Guidance. JACC Advances 2025, 4: 101797. PMID: 40373523, PMCID: PMC12144438, DOI: 10.1016/j.jacadv.2025.101797.Peer-Reviewed Original ResearchSurvivors of sudden cardiac arrestSudden cardiac arrestMental healthHealth care seekingMental health reviewPost-traumatic stress symptomsUntreated mental healthCardiac arrestCare-seekingCare planningImprove wellnessHealth reviewStress symptomsPost-SCAUsual lifeHealthFollow-upDefibrillation shocksManagement guidanceExperience shockSymptomsICDImplantable cardiac defibrillator shockDefibrillationAdherenceDiabetes Status and Long-Term Mortality and Major Amputation Outcomes Following Revascularization in Chronic Limb Threatening Ischemia
Callegari S, Romain G, Aggarwal A, Cleman J, Smolderen K, Mena-Hurtado C. Diabetes Status and Long-Term Mortality and Major Amputation Outcomes Following Revascularization in Chronic Limb Threatening Ischemia. Journal Of Vascular Surgery 2025 PMID: 40348290, DOI: 10.1016/j.jvs.2025.04.065.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaLower-extremity bypassSub-hazard ratiosPeripheral vascular interventionsDM statusRisk of deathLimb-threatening ischemiaTeam-based careShared decision-makingCumulative incidenceDiabetes mellitusMedicare claims dataCumulative incidence of mortalityAll-cause mortalityType of revascularizationAmputation outcomesCare offerFine-Gray modelClaims dataCumulative incidence of deathLong-term mortalityMortality riskCox regression modelsHazard ratioDiabetes statusVARIABILITY IN GUIDELINE-DIRECTED MEDICAL THERAPY AMONG SITES AND OPERATORS AND PATIENT FACTORS ASSOCIATED WITH ITS USAGE FOLLOWING CAROTID ARTERY STENTING
Jallow M, Romain G, AL Mouslmani M, Rahman M, Tapia C, Kansal D, Jamil Y, Pajarillo C, Mena G, Mubarak E, Vashist A, Filho J, Smolderen K, Hurtado C. VARIABILITY IN GUIDELINE-DIRECTED MEDICAL THERAPY AMONG SITES AND OPERATORS AND PATIENT FACTORS ASSOCIATED WITH ITS USAGE FOLLOWING CAROTID ARTERY STENTING. Journal Of The American College Of Cardiology 2025, 85: 2399. DOI: 10.1016/s0735-1097(25)02883-9.Peer-Reviewed Original ResearchCHRONIC PAIN DISORDERS, OPIOID USE AND 1-YEAR MORTALITY OUTCOMES IN PATIENTS UNDERGOING PERIPHERAL VASCULAR INTERVENTION FOR CHRONIC LIMB THREATENING ISCHEMIA
Rahman M, Romain G, Tapia C, AL Mouslmani M, Jallow M, Mena G, Mubarak E, Filho J, Vashist A, Hurtado C, Smolderen K. CHRONIC PAIN DISORDERS, OPIOID USE AND 1-YEAR MORTALITY OUTCOMES IN PATIENTS UNDERGOING PERIPHERAL VASCULAR INTERVENTION FOR CHRONIC LIMB THREATENING ISCHEMIA. Journal Of The American College Of Cardiology 2025, 85: 2405. DOI: 10.1016/s0735-1097(25)02889-x.Peer-Reviewed Original ResearchBLOOD PRESSURE CONTROL AND RISK OF CARDIOVASCULAR AND LIMB EVENTS IN PERIPHERAL ARTERY DISEASE PATIENTS
Girotra S, Gupta A, Chan P, Li Q, Lund B, vaughansarrazin M, Nguyen C, Kumbhani D, Gobbel G, Arya S, Bavry A, Smolderen K, Hoffman R, Vongpatanasin W, De Lemos J, Beckman J. BLOOD PRESSURE CONTROL AND RISK OF CARDIOVASCULAR AND LIMB EVENTS IN PERIPHERAL ARTERY DISEASE PATIENTS. Journal Of The American College Of Cardiology 2025, 85: 435. DOI: 10.1016/s0735-1097(25)00919-2.Peer-Reviewed Original ResearchOutcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial Presented at the Southern Association for Vascular Surgery Forty-ninth Annual Meeting, Frenchman's Reef in St. Thomas, USVI, January 22-25, 2025.
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial Presented at the Southern Association for Vascular Surgery Forty-ninth Annual Meeting, Frenchman's Reef in St. Thomas, USVI, January 22-25, 2025. European Journal Of Vascular And Endovascular Surgery 2025, 69: e262-e263. DOI: 10.1016/j.ejvs.2025.02.053.Peer-Reviewed Original ResearchLong‐Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long‐Term Survival Study (PEARLS)
Girotra S, Li Q, Vaughan‐Sarrazin M, Lund B, Al‐Garadi M, Beckman J, Nathani R, Hoffman R, Chan P, Banerjee S, Tsai S, Kumbhani D, Minniefield‐Young N, Smolderen K, Arya S, Nguyen C, Matheny M, Gobbel G. Long‐Term Outcomes of Peripheral Artery Disease in Veterans: Analysis of the Peripheral Artery Disease Long‐Term Survival Study (PEARLS). Journal Of The American Heart Association 2025, 14: e038403. PMID: 40118806, PMCID: PMC12132885, DOI: 10.1161/jaha.124.038403.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPeripheral arterial diseaseHealth AdministrationIntegrated health systemOutcomes of peripheral artery diseaseDiagnosis of peripheral arterial diseaseToe-brachial index valuesPrevalence of hypertensionLimb eventsChronic obstructive pulmonary diseaseAnkle-brachial indexImprove careHealth systemObstructive pulmonary diseaseCardiovascular eventsHigh-risk groupNational registryArtery diseaseVeteransIncidence of cardiovascular eventsRegistryIncidence of deathPulmonary diseasePatient yearsStudy end pointEffect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis
Edjimbi J, Shah N, Kwaah P, Grimshaw A, Regan C, Nagpal S, Attaran R, Chaar C, Romain G, Smolderen K, Mena-Hurtado C. Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis. Journal Of Vascular Surgery 2025, 81: 1518-1528.e13. PMID: 40015609, DOI: 10.1016/j.jvs.2025.02.018.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseHospital readmissionRelative riskDiabetes mellitusRandom-effects meta-analysisIncreased riskMeta-analysisAssociation of DMExtremity revascularizationMortality riskWound infectionRisk estimatesAssociated with diabetes mellitusClinical outcomesSystematic reviewArtery diseaseSystematic searchObservational studyWound infection riskReadmissionEffects of diabetesAmputationRiskHospitalAssociation between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease
Callegari S, Romain G, Capuano I, Cleman J, Scierka L, Smolderen K, Mena-Hurtado C. Association between guideline-directed medical therapy and reintervention risk following peripheral vascular interventions in patients with peripheral artery disease. Vascular Medicine 2025, 30: 293-301. PMID: 39992181, DOI: 10.1177/1358863x251320347.Peer-Reviewed Original ResearchGuideline-directed medical therapyGuideline-directed medical therapy ratesPeripheral vascular interventionsPeripheral arterial diseaseReintervention outcomesReintervention riskMedical therapyArtery diseaseVascular interventionsAngiotensin receptor blockersCompeting risk analysisScore-matched cohortReceipt of statinsPost-PVIAngiotensin-converting enzymeReceptor blockersReinterventionMedicare outcomesMedication adherencePatientsRegistry dataTherapyOutcomesReceiptRiskUnderstanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association
Smolderen K, Ujueta F, Behan D, Vlaeyen J, Jackson E, Peters M, Whipple M, Phillips K, Chung J, Mena-Hurtado C, Research O. Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association. Circulation Cardiovascular Quality And Outcomes 2025, 18: e000135. PMID: 39925269, DOI: 10.1161/hcq.0000000000000135.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseArtery diseaseMultimodal pain management strategiesPain experienceAtypical leg painChronic pain syndromesGeneration of painMultimodal pain managementChronic pain experiencePain management strategiesIschemic rest painPhantom limb painAmerican Heart AssociationNeuropathic painLeg painNeuropathic mechanismsPain syndromeOpioid useChronic painRest painPain managementHeart AssociationLimb painClinical subgroupsIntermittent claudicationHealth Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study
Mosarla R, Chowdhury M, Smolderen K, Mena-Hurtado C, Spertus J, Yeh R, Secemsky E. Health Status Improvement After Peripheral Vascular Intervention: Insights From the LIBERTY 360 Study. The American Journal Of Cardiology 2025, 243: 22-31. PMID: 39894333, DOI: 10.1016/j.amjcard.2025.01.017.Peer-Reviewed Original ResearchPredictor of health statusHealth statusEQ-VASAssociated with health statusHealth status measuresTarget vessel/lesion revascularizationTotal scoreBaseline health statusAll-cause deathImprove health statusPeripheral endovascular interventionsHealth status improvementChronic limb-threatening ischemiaRepeated measures modelPeripheral arterial disease severitySymptomatic peripheral arterial diseaseStatus measuresPeripheral arterial diseaseLimb-threatening ischemiaLong-term improvementPeripheral vascular interventionsStatus improvementHealthMultivariate regressionClaudicationOutcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial. Journal Of Vascular Surgery 2025, 81: 945-956.e3. PMID: 39846933, DOI: 10.1016/j.jvs.2024.12.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChronic Limb-Threatening IschemiaEndovascular ProceduresFemaleGlomerular Filtration RateHumansIschemiaKidneyLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaChronic kidney diseaseDialysis-dependent patientsBEST-CLIChronic kidney disease stagePrimary trial outcomeRisk of amputationAssociated with lower mortalityEndovascular therapyAll-cause mortalityHigh risk of poor outcomesRisk of poor outcomesEndovascular revascularizationKidney diseaseBEST-CLI trialOutcomes of lower extremity revascularizationAssociated with better survivalMultivariate Cox regression analysisBest Surgical TherapyIncreased reintervention rateStage 4 CKD patientsRisk of reinterventionGroup C patientsAdverse limb eventsChronic kidney disease severityDefining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting
Kluger J, Romain G, Mena‐Hurtado C, Grubman S, Pajarillo C, Cleman J, Scierka L, Smolderen K. Defining Thresholds for Meaningful Health Status Changes Following Transfemoral Carotid Artery Stenting. Catheterization And Cardiovascular Interventions 2025, 105: 927-937. PMID: 39789704, DOI: 10.1002/ccd.31410.Peer-Reviewed Original ResearchConceptsMinimal clinically important differenceHealth status changesHealth statusSF-36Visual analog scaleEQ-5DDistribution-based MCIDPhysical component scoreCarotid artery stentingDisease-specific instrumentHealth status improvementTransfemoral carotid artery stentingSymptom statusClinically important differenceTF-CASStatus changesGeneric instrumentsArtery stentingRegistry dataComponent scoresImportant differencePatients no changeStatus improvementAsymptomatic carotid stenosisHealthInteraction of anxiety symptoms with peripheral artery disease treatment strategies and health status outcomes
Odu T, Romain G, Scierka L, Cleman J, Callegari S, Jacque F, Mena-Hurtado C, Smolderen K. Interaction of anxiety symptoms with peripheral artery disease treatment strategies and health status outcomes. Vascular Medicine 2025, 30: 216-217. PMID: 39760470, DOI: 10.1177/1358863x241306406.Peer-Reviewed Original Research
2024
New horizons in nuclear cardiology: Imaging of peripheral arterial disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New horizons in nuclear cardiology: Imaging of peripheral arterial disease. Journal Of Nuclear Cardiology 2024, 46: 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionLack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index
Pajarillo C, Romain G, Cleman J, Scierka L, Grubman S, Schenck C, Kluger J, Smolderen K, Mena-Hurtado C. Lack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index. Vascular Medicine 2024, 30: 27-37. PMID: 39526556, DOI: 10.1177/1358863x241292545.Peer-Reviewed Original ResearchDistressed Communities IndexCommunity distressDistress groupCarotid artery stentingDistressed Communities Index scoreHierarchical Cox regressionCumulative incidence function curvesSocial determinantsNon-Hispanic/LatinoStroke incidenceAccess barriersFine-Gray modelArtery stentingDistressKaplan-Meier survival curvesVascular Quality Initiative databaseZip-codeFine-GrayMortality incidenceCox regressionAssociationAnalyzed patientsNo significant differenceMortalityLack of diversityPrediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication
Peri-Okonny P, Romain G, Callegari S, Cleman J, Vashist A, Smolderen K, Mena-Hurtado C. Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication. Annals Of Vascular Surgery 2024, 110: 314-322. PMID: 39395588, DOI: 10.1016/j.avsg.2024.08.016.Peer-Reviewed Original ResearchHealth statusPeripheral arterial diseaseEQ-5D VASPeripheral vascular interventionsPredictor of future health statusPredictor of health statusDrug-coated balloonLower extremity peripheral arterial diseaseHealth status outcomesFuture health statusEQ-5D-3LHistory of deep venous thrombosisImprove patient outcomesStatus outcomesPrediction of health statusChronic lung diseaseDeep venous thrombosisPlain balloon angioplastyPatient outcomesDisease managementExtremity interventionsApproach to treatmentSD ageVenous thrombosisBaseline characteristicsTCT-702 Shockwave Intravascular Lithotripsy in Calcified Common Femoral Lesions in Patients With Peripheral Arterial Disease: 30-Day Health Status Outcomes From CRUSH-PAD Trial
Rahman, Romain G, Cleman J, Aggarwal A, Smolderen K, Mena-Hurtado C. TCT-702 Shockwave Intravascular Lithotripsy in Calcified Common Femoral Lesions in Patients With Peripheral Arterial Disease: 30-Day Health Status Outcomes From CRUSH-PAD Trial. Journal Of The American College Of Cardiology 2024, 84: b276-b277. DOI: 10.1016/j.jacc.2024.09.839.Peer-Reviewed Original ResearchCombining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study
Mao J, Matheny M, Smolderen K, Mena-Hurtado C, Sedrakyan A, Goodney P. Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study. BMJ Open 2024, 14: e085806. PMID: 39327057, PMCID: PMC11429269, DOI: 10.1136/bmjopen-2024-085806.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataClinical Research NetworkAmputation-free survivalPeripheral vascular interventionsResearch NetworkINSIGHT Clinical Research NetworkNew York CityHealth record dataIncreased riskLong-term outcomes of interventionsSecondary outcome measuresOutcomes of interventionsIncreased risk of deathYork CityRisk of deathObservational cohort studyHealth recordsRegistry dataClinical registryVascular Quality Initiative registryCohort studyOutcome assessmentRecord dataLong-term outcomes
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