2022
The shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale
Scierka LE, Mena-Hurtado C, Shishehbor MH, Spertus JA, Nagpal S, Babrowski T, Bunte MC, Politano A, Humphries M, Chung J, Kirksey L, Alabi O, Soukas P, Parikh S, Faizer R, Fitridge R, Provance J, Romain G, McMillan N, Stone N, Scott K, Fuss C, Pacheco CM, Gosch K, Harper-Brooks A, Smolderen KG, Consortium O. The shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale. IJC Heart & Vasculature 2022, 39: 100971. PMID: 35198727, PMCID: PMC8850321, DOI: 10.1016/j.ijcha.2022.100971.Peer-Reviewed Original ResearchCritical limb ischemiaTreatment preferencesPeripheral artery diseaseProspective observational registryPatient-centered outcomesPatterns of carePoor wound healingHealth status outcomesProcess of careCLI careObservational registryLimb ischemiaPatient characteristicsArtery diseaseVascular centersVital statusMean agePatient preferencesPatient's perspectiveSevere formPatientsPsychosocial factorsStatus outcomesHealth statusCare experiencesReal‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease
Nagpal S, Scierka LE, Castro‐Dominguez Y, Kansal D, Kunnirickal S, Hussain Y, Love K, Aboian E, Smolderen KG, Mena‐Hurtado C. Real‐world VASCADE closure device versus manual compression use and outcomes in patients with severe common femoral artery disease. Catheterization And Cardiovascular Interventions 2022, 100: 776-784. PMID: 36129818, DOI: 10.1002/ccd.30405.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsManual compressionClosure deviceCommon femoral artery diseaseVascular Quality Initiative databaseFemoral artery diseasePropensity-matched cohortPseudoaneurysm rateRetroperitoneal bleedingArtery diseaseRetrospective reviewMean ageBaseline variablesInstitutional databaseNonsignificant reductionNonsignificant decreaseVascular interventionsMortality ratePatientsCompression useCollagen plugDiseaseInitiative databaseProcedural metricsDevice useAntiplatelet regimens following carotid artery revascularization
Lee M, Ahmed ZV, Huang J, Brice A, Arham A, Castro-Dominguez Y, Aboian E, Nagpal S, Smolderen KG, Mena-Hurtado C. Antiplatelet regimens following carotid artery revascularization. American Heart Journal 2022, 253: 48-52. PMID: 35863439, DOI: 10.1016/j.ahj.2022.07.004.Peer-Reviewed Original ResearchConceptsDual antiplatelet therapySingle antiplatelet therapyCarotid artery stentingCarotid endarterectomyAntiplatelet therapyReal-world clinical practiceCarotid artery revascularizationLow adherence ratesArtery revascularizationArtery stentingAdherence ratesClinical practicePatientsTherapyEngland dataHigh percentageRevascularizationAntiplateletEndarterectomyStenting
2024
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
Regan C, Scierka L, Dardik A, Tonnessen B, Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 33: 466-471. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesComparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-cause mortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity score
2023
Community distress and risk of adverse outcomes after peripheral vascular intervention
Schenck C, Strand E, Smolderen K, Romain G, Nagpal S, Cleman J, Blume P, Mena-Hurtado C. Community distress and risk of adverse outcomes after peripheral vascular intervention. Journal Of Vascular Surgery 2023, 78: 166-174.e3. PMID: 36944389, PMCID: PMC11146282, DOI: 10.1016/j.jvs.2023.03.027.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsDistressed Communities IndexMajor amputationRisk of mortalityAdverse outcomesVascular interventionsVascular Quality Initiative databaseDCI scoresCommunity distressCox regression modelTime-dependent receiverCharacteristic curve analysisClinical characteristicsFinal cohortPrimary outcomeClinical outcomesCardiovascular diseasePatientsAmputationZip code dataMortalityRisk categoriesCurve analysisInitiative databaseOutcomes
2021
Trends in drug-coated device use for peripheral artery disease: Insights from the Vascular Quality Initiative (VQI)
Pichert MD, Smolderen KG, Castro-Dominguez Y, Jelani QU, Nagpal S, Provance JB, Huang J, Malik AO, Secemsky EA, Derbas LA, Mena-Hurtado CI. Trends in drug-coated device use for peripheral artery disease: Insights from the Vascular Quality Initiative (VQI). Vascular Medicine 2021, 27: 73-74. PMID: 34610776, DOI: 10.1177/1358863x211043567.Peer-Reviewed Original ResearchAssociation of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean agePERIPHERAL ARTERY DISEASE AND SARS-COV-2 OUTCOMES IN THE YALE DOM-COVX REGISTRY
Smolderen K, Nagpal S, Simonov M, Arora T, Hurtado C. PERIPHERAL ARTERY DISEASE AND SARS-COV-2 OUTCOMES IN THE YALE DOM-COVX REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 1834. PMCID: PMC8091368, DOI: 10.1016/s0735-1097(21)03190-9.Peer-Reviewed Original ResearchTELEHEALTH PROVIDER PERSPECTIVES DURING COVID-19: INSIGHTS FROM AN ACADEMIC CARDIOLOGY PRACTICE
Lee M, Luna P, Lynch S, Nagpal S, Dominguez Y, Ahmed Z, Brice A, Arham A, Smolderen K, Hurtado C. TELEHEALTH PROVIDER PERSPECTIVES DURING COVID-19: INSIGHTS FROM AN ACADEMIC CARDIOLOGY PRACTICE. Journal Of The American College Of Cardiology 2021, 77: 3212. PMCID: PMC8091235, DOI: 10.1016/s0735-1097(21)04567-8.Peer-Reviewed Original ResearchGUIDELINE CONCORDANT ANTIPLATELET REGIMENS IN PATIENTS WHO UNDERWENT CAROTID ARTERY REVASCULARIZATION: INSIGHTS FROM THE VASCULAR QUALITY INITIATIVE REGISTRY
Ahmed Z, Lee M, Huang J, Brice A, Arham A, Dominguez Y, Aboian E, Nagpal S, Smolderen K, Hurtado C. GUIDELINE CONCORDANT ANTIPLATELET REGIMENS IN PATIENTS WHO UNDERWENT CAROTID ARTERY REVASCULARIZATION: INSIGHTS FROM THE VASCULAR QUALITY INITIATIVE REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 1078. DOI: 10.1016/s0735-1097(21)02437-2.Peer-Reviewed Original ResearchTRENDS IN DRUG COATED DEVICE USE FOR TREATMENT OF PERIPHERAL ARTERY DISEASE IN REAL WORLD PRACTICE
Pichert M, Jelani Q, Dominguez Y, Huang J, Nagpal S, Secemsky E, Derbas L, Malik A, Smolderen K, Hurtado C. TRENDS IN DRUG COATED DEVICE USE FOR TREATMENT OF PERIPHERAL ARTERY DISEASE IN REAL WORLD PRACTICE. Journal Of The American College Of Cardiology 2021, 77: 928. DOI: 10.1016/s0735-1097(21)02287-7.Peer-Reviewed Original ResearchFRAILTY AND OUTCOMES FOLLOWING PERCUTANEOUS VASCULAR INTERVENTIONS IN LOWER-EXTREMITY PERIPHERAL ARTERY DISEASE: INSIGHTS FROM THE VASCULAR QUALITY INITIATIVE
Al-Damluji M, Smolderen K, Huang J, Guzman R, Nagpal S, Hurtado C. FRAILTY AND OUTCOMES FOLLOWING PERCUTANEOUS VASCULAR INTERVENTIONS IN LOWER-EXTREMITY PERIPHERAL ARTERY DISEASE: INSIGHTS FROM THE VASCULAR QUALITY INITIATIVE. Journal Of The American College Of Cardiology 2021, 77: 1230. DOI: 10.1016/s0735-1097(21)02589-4.Peer-Reviewed Original ResearchSafety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions
Sheikh AB, Llanos-Chea F, Jelani QU, Anantha-Narayanan M, Attaran R, Schneider M, Ionescu C, Regan C, Nagpal S, Smolderen KG, Mena-Hurtado C. Safety and efficacy outcomes of the Pioneer Plus catheter in endovascular revascularization of lower extremity chronic total occlusions. Journal Of Vascular Surgery 2021, 74: 746-755. PMID: 33592298, DOI: 10.1016/j.jvs.2021.01.045.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsAdverse limb eventsDevice-related complicationsProcedure-related complicationsProcedure-related outcomesProcedural successEfficacy outcomesPseudoaneurysm formationSafety outcomesLimb eventsLower extremity chronic total occlusionMajor adverse cardiovascular eventsChronic total occlusion interventionAccess site hematomaAcute arterial thrombosisAcute limb ischemiaAdverse cardiovascular eventsProvider-level factorsArteriovenous fistula formationHigh-volume centersChronic total occlusionMajor bleedingPreprocedural symptomsCardiovascular eventsCatheter use
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategiesImpact of Kidney Disease on Peripheral Arterial Interventions: A Systematic Review and Meta-Analysis
Anantha-Narayanan M, Sheikh AB, Nagpal S, Smolderen KG, Turner J, Schneider M, Llanos-Chea F, Mena-Hurtado C. Impact of Kidney Disease on Peripheral Arterial Interventions: A Systematic Review and Meta-Analysis. American Journal Of Nephrology 2020, 51: 527-533. PMID: 32570255, DOI: 10.1159/000508575.Peer-Reviewed Original ResearchConceptsCKD/ESRDCritical limb ischemiaPAD interventionsMajor amputationEarly mortalitySystematic reviewCKD/ESRD patientsPeripheral arterial disease interventionsHigher major amputationOutcomes of patientsPeripheral arterial interventionsSuch comorbid conditionsESRD patientsLimb ischemiaArterial interventionsComorbid conditionsRandomized trialsKidney diseasePatient populationESRDObservational studyRisk populationsFunnel plotPatientsMeta-AnalysisUtility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis
Sheikh AB, Anantha-Narayanan M, Smolderen KG, Jelani QU, Nagpal S, Schneider M, Llanos F, Ionescu C, Regan C, Attaran R, Altin SE, Mena-Hurtado C. Utility of Intravascular Ultrasound in Peripheral Vascular Interventions: Systematic Review and Meta-Analysis. Vascular And Endovascular Surgery 2020, 54: 413-422. PMID: 32338163, DOI: 10.1177/1538574420920998.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsPeriprocedural adverse eventsVascular complicationsAdverse eventsIntravascular ultrasoundPrimary patencyCause mortalityTechnical successMyocardial infarctionObservational studyVascular interventionsEnd pointSimilar patency ratesSimilar primary patencyPrimary end pointRate of reinterventionSecondary end pointsPeripheral arterial diseaseImproved clinical outcomesIVUS groupAmputation rateArterial diseaseClinical outcomesPatency ratesLower risk
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