2024
New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New Horizons in Nuclear Cardiology: Imaging of Peripheral Arterial Disease. Journal Of Nuclear Cardiology 2024, 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionPrediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication
Peri-Okonny P, Romain G, Callegari S, Cleman J, Vashist A, Smolderen K, Mena-Hurtado C. Prediction of Health Status in Patients Undergoing Lower Extremity Intervention for Claudication. Annals Of Vascular Surgery 2024, 110: 314-322. PMID: 39395588, DOI: 10.1016/j.avsg.2024.08.016.Peer-Reviewed Original ResearchHealth statusPeripheral arterial diseaseEQ-5D VASPeripheral vascular interventionsPredictor of future health statusPredictor of health statusDrug-coated balloonLower extremity peripheral arterial diseaseHealth status outcomesFuture health statusEQ-5D-3LHistory of deep venous thrombosisImprove patient outcomesStatus outcomesPrediction of health statusChronic lung diseaseDeep venous thrombosisPlain balloon angioplastyPatient outcomesDisease managementExtremity interventionsApproach to treatmentSD ageVenous thrombosisBaseline characteristicsAssociation of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry
Cleman J, Romain G, Scierka L, Labrosciano C, Bradley B, Fitridge R, Beltrame J, Shishehbor M, Spertus J, Mena-Hurtado C, Smolderen K. Association of health status and hospitalization risk for peripheral artery disease in the PORTRAIT registry. Vascular Medicine 2024, 29: 664-674. PMID: 39319857, DOI: 10.1177/1358863x241274758.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseED visitsHealth statusHospital admissionHealthcare utilizationPAD-specific health statusEmergency departmentCause-specific hospital admissionsAssociation of health statusPatient-reported outcome measuresPatient's risk of hospitalizationBaseline health statusAll-cause hospital admissionsCox proportional hazards modelsRisk of hospitalizationOverall summary scorePAQ scoresProportional hazards modelSummary scoreOutcome measuresHospitalization riskArtery diseaseVisitsHazards modelCompeting risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease
Callegari S, Smolderen K, Cleman J, Mena-Hurtado C, Romain G. Competing risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease. Vascular Medicine 2024, 29: 496-506. PMID: 39219174, PMCID: PMC11575932, DOI: 10.1177/1358863x241268727.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAmputation riskTime-to-event analysisPeripheral arterial diseaseLower-extremity peripheral arterial diseaseCumulative incidence functionCompeting risk analysisAmputation incidenceAmputation dataMedicare claimsLimb-threatening ischemiaVascular Quality Initiative registryMortality riskOutcomes researchPeripheral vascular interventionsArtery diseaseAmputationVascular outcomesCox regressionRiskMortalityCohortVascular interventionsTime-to-event methodsPatientsTwelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting
Smolderen K, Romain G, Cleman J, Callegari S, Peri-Okonny P, Mena-Hurtado C. Twelve-month health status response after peripheral vascular intervention for femoropopliteal lesions using Zilver PTX databases focusing on the role of preprocedural health status, comorbid risks, and global setting. Journal Of Vascular Surgery 2024, 81: 210-220.e7. PMID: 39214426, DOI: 10.1016/j.jvs.2024.08.035.Peer-Reviewed Original ResearchMinimal clinically important differenceEQ-5D indexHealth statusPeripheral vascular interventionsPeripheral arterial diseaseEQ-5DNon-respondersValue-based careEuroQol-5D-3LClinically important differenceSecondary data analysisFemoropopliteal peripheral vascular interventionsStable health statusLogistic regression modelsArtery diseaseSymptomatic peripheral arterial diseaseStatus responseTailored resourcesVascular interventionsSingle-arm studyImportant differenceCarotid artery diseaseComorbidity riskEnrolling centersPatient characteristicsAssociation of social support and health status outcomes in peripheral artery disease
Callegari S, Romain G, Cleman J, Scierka L, Peri-Okonny P, Spertus J, Labrosciano C, Beltrame J, Abbott J, Fitridge R, Mena-Hurtado C, Smolderen K. Association of social support and health status outcomes in peripheral artery disease. Journal Of Vascular Surgery 2024, 80: 1824-1835.e7. PMID: 39151740, PMCID: PMC11585422, DOI: 10.1016/j.jvs.2024.08.010.Peer-Reviewed Original ResearchENRICHD Social Support InventoryLow social supportLow perceived social supportGeneric health statusHealth status outcomesPeripheral arterial diseaseSocial supportHealth statusBiopsychosocial variablesStatus outcomesAssociation with health status outcomesAssociated with lower health statusDisease-specific health statusBaseline perceived social supportImprove social supportLower health statusSocial Support InventoryImprove health statusPerceived social supportDisease-specificEQ-5D-3LCare of patientsQuality of lifeEQ-5D-3L indexBiopsychosocial factorsAddressing Psychosocial Care Needs in Women with Peripheral Artery Disease
Mubarak E, Cleman J, Romain G, Mena-Hurtado C, Smolderen K. Addressing Psychosocial Care Needs in Women with Peripheral Artery Disease. Current Cardiology Reports 2024, 26: 1085-1095. PMID: 39073508, DOI: 10.1007/s11886-024-02106-6.Peer-Reviewed Original ResearchVascular careIncreased psychosocial riskPsychosocial care needsIntegration of careMental health comorbiditiesBehavioral health careReviewPeripheral artery diseaseManagement of individualsCare integrationIllness perceptionsGender-based factorsCare needsHealthcare accessHealth behaviorsHealth comorbiditiesSubstance use disordersCare strategiesHealth carePeripheral arterial diseasePsychosocial comorbiditiesReimbursement structuresClinician educationCare paradigmUnique sexPsychosocial risksImpact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry
Cerrud-Rodriguez R, Romain G, Hussain Y, Cleman J, Callegari S, Scierka L, Smolderen K, Mena-Hurtado C. Impact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry. Journal Of Vascular Surgery 2024, 80: 780-790.e10. PMID: 38735596, DOI: 10.1016/j.jvs.2024.04.061.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseHealth statusChronic total occlusionChronic total occlusion lesionsPAD-specific health statusEarly invasive treatmentMultilevel generalized linear regression modelsPeripheral arterial disease symptomsLower extremity peripheral arterial diseaseBaseline health statusHealth status outcomesInvasive treatmentHealth status trajectoriesNon-invasive treatmentPatients' health statusImpact of early interventionHigh health statusFollow-upPeripheral arterial disease patientsSymptomatic peripheral arterial diseaseMonths of follow-upPresence of chronic total occlusionNon-invasive treatment strategyStatus outcomesMulti-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice
Callegari S, Feher A, Smolderen K, Mena-Hurtado C, Sinusas A. Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice. American Heart Journal Plus Cardiology Research And Practice 2024, 42: 100400. PMID: 38779485, PMCID: PMC11108852, DOI: 10.1016/j.ahjo.2024.100400.Peer-Reviewed Original ResearchPeripheral arterial diseaseMicrovascular diseasePeripheral microcirculationArtery diseaseEvaluation of response to therapyResponse to therapyManagement of peripheral arterial diseaseImprove risk stratificationOutcomes of peripheral artery diseaseAssessment of perfusionPathophysiology of peripheral arterial diseaseRisk of mortalityMolecular imaging studiesMulti-modal imagesPredictors of amputationRisk stratificationPre-clinicalImaging studiesClinical perfusionProcedural treatmentsClinical practicePersonalized managementMicrocirculationDiseasePerfusionAbstract 1150: Effect Of Diabetes On Clinical Outcomes In Patients With Peripheral Arterial Disease Undergoing Lower Extremity Revascularization: A Systematic Review And Meta-analysis
EDJIMBI J, Aziri B, Begic E, Cleman J, Smolderen K, Mena-Hurtado C. Abstract 1150: Effect Of Diabetes On Clinical Outcomes In Patients With Peripheral Arterial Disease Undergoing Lower Extremity Revascularization: A Systematic Review And Meta-analysis. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1150-a1150. DOI: 10.1161/atvb.44.suppl_1.1150.Peer-Reviewed Original ResearchPeripheral arterial diseaseLower extremity revascularizationLimb amputationRisk of major limb amputationOpen lower extremity revascularizationMajor limb amputationIncreased riskMeta-analysisImpact of diabetesEffects of diabetesExtremity revascularizationRandom-effects modelAssociated with diabetesClinical outcomesLower-extremity revascularizationSystematic reviewCochrane DatabaseSystematic searchReview ManagerObservational studyAmputationDiabetesAdverse cardiovascular eventsFollow-upDays of follow-upClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
Regan C, Scierka L, Dardik A, Tonnessen B, Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 33: 466-471. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesPAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX
Alashi A, Hurtado C, Romain G, Callegari S, Jacque F, Sinusas A, Smolderen K. PAIN PROFILES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: ROLE OF PSYCHOSOCIAL FACTORS AND FEMALE SEX. Journal Of The American College Of Cardiology 2024, 83: 2284. DOI: 10.1016/s0735-1097(24)04274-8.Peer-Reviewed Original ResearchASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE
Jacque F, Romain G, Peri-Okonny P, Sinusas A, Callegari S, Cleman J, Scierka L, Mares A, Hurtado C, Smolderen K. ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 2308. DOI: 10.1016/s0735-1097(24)04298-0.Peer-Reviewed Original ResearchImpact of comorbid opioid use disorder and major depressive disorder on healthcare utilization outcomes in patients with peripheral artery disease: A National Readmission Database analysis
Amenyedor K, Lee M, Algara M, Siddiqui W, Hardt M, Romain G, Mena-Hurtado C, Smolderen K. Impact of comorbid opioid use disorder and major depressive disorder on healthcare utilization outcomes in patients with peripheral artery disease: A National Readmission Database analysis. Vascular Medicine 2024, 29: 163-171. PMID: 38391134, DOI: 10.1177/1358863x241228540.Peer-Reviewed Original ResearchComorbid opioid use disorderOpioid use disorderPeripheral arterial diseaseDepressive disorderUse disorderArtery diseaseHealthcare utilization outcomesICD-9/10 diagnosis codesPain management strategiesMultivariate logistic regression modelNational Readmission DatabaseHierarchical multivariable logistic regression modelsLength of stayLogistic regression modelsMDDMedian stayPrimary outcomeHighest median costReadmissions DatabasePatientsMedian costStudy populationUtilization outcomesWeighted admissionsDiagnosis codesPsychosocial and socioeconomic factors are most predictive of health status in patients with claudication
Scierka L, Peri-Okonny P, Romain G, Cleman J, Spertus J, Fitridge R, Secemsky E, Patel M, Gosch K, Mena-Hurtado C, Smolderen K. Psychosocial and socioeconomic factors are most predictive of health status in patients with claudication. Journal Of Vascular Surgery 2024, 79: 1473-1482.e5. PMID: 38266885, DOI: 10.1016/j.jvs.2024.01.021.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral Artery Questionnaire summary scoresPeripheral arterial diseaseHealth statusSummary scoreSymptomatic peripheral arterial diseaseSocial supportInsurance statusPAD-specific health statusHierarchical multivariable linear regression modelSocioeconomic patient characteristicsLow social supportPeripheral artery disease cohortPeripheral artery questionnaire scoresImprove health statusComparative effectiveness researchDiagnosis of depressionPatient characteristicsMultivariate linear regression modelPrediction of health statusDepression scoresLinear regression modelsAge of patientsDuration of symptomsAnxiety scores
2023
Disparities in Diagnosis, Treatment, and Outcomes of Peripheral Artery Disease JACC Scientific Statement
McDermott M, Ho K, Alabi O, Criqui M, Goodney P, Hamburg N, McNeal D, Pollak A, Smolderen K, Bonaca M. Disparities in Diagnosis, Treatment, and Outcomes of Peripheral Artery Disease JACC Scientific Statement. Journal Of The American College Of Cardiology 2023, 82: 2312-2328. PMID: 38057074, DOI: 10.1016/j.jacc.2023.09.830.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRate of amputationAmputation ratePeripheral arterial disease prevalencePrevalence of peripheral arterial diseaseLower extremity peripheral arterial diseasePeripheral arterial disease outcomesHealth policy changesCulturally appropriate messagesHigher amputation rateOptimal medical careHealth carePatient educationDisparity eliminationMobility lossSocioeconomic statusClinician educationMedical careImprove accessLower extremity revascularizationUnited StatesAtypical symptomsOlder ageDisparitiesAmputationPredictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study
Pokharel Y, Kokkinidis D, Wang J, Gosch K, Safley D, Spertus J, Mena-Hurtado C, Smolderen K. Predictors of Revascularization in Lower-Extremity Peripheral Artery Disease: Insights From the PORTRAIT Study. Journal Of Endovascular Therapy 2023, 32: 423-430. PMID: 37309164, DOI: 10.1177/15266028231179574.Peer-Reviewed Original ResearchPredictors of revascularizationEarly revascularizationPeripheral artery diseaseExtensive diseasePAD symptomsSymptom burdenArtery diseaseOdds ratioLower Extremity Peripheral Artery DiseaseAnkle-brachial index scoreGoal-directed medical therapyEarly revascularization proceduresKnee arterial segmentsLifestyle-limiting claudicationRutherford class 3Peripheral arterial diseaseMonths of presentationPatient-level predictorsLower extremity PADMain predictorsMedian odds ratioHierarchical logistic regressionSymptomatic PADDisease guidelinesMedical therapyObesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease
Scierka L, Peri-Okonny P, Romain G, Mena-Hurtado C, Smolderen K. Obesity prevalence and variability in management practices for patients with symptomatic peripheral artery disease. Obesity Research & Clinical Practice 2023, 17: 264-268. PMID: 37225553, DOI: 10.1016/j.orcp.2023.05.002.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseWeight loss medicationsObesity management strategiesMedian odds ratioDietary counselingLower extremity peripheral arterial diseaseSymptomatic peripheral artery diseaseDietary management strategiesSymptomatic PAD patientsPeripheral artery diseaseObesity prevalence ratesPrevalence of obesityPoor disease outcomeModifiable comorbiditiesPORTRAIT registryPAD patientsArtery diseaseArterial diseaseTreatment modalitiesObesity prevalenceOdds ratioDisease outcomePrevalence ratesPAD managementObesity
2021
Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry
Smolderen KG, Lee M, Arora T, Simonov M, Mena-Hurtado C. Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry. Current Problems In Cardiology 2021, 47: 101007. PMID: 34627824, PMCID: PMC8496926, DOI: 10.1016/j.cpcardiol.2021.101007.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseSARS-CoV-2Myocardial infarctionMajor adverse cardiovascular eventsAdverse cardiovascular eventsPeripheral artery diseaseOdds of mortalityCOVID-19 infectionCOVID-19 outcomesLogistic regression modelsCardiovascular eventsArtery diseaseArterial diseaseMean ageRisk factorsWorse outcomesPatientsMinority raceMortalityRegistryStrokeDiseaseMACERegression modelsOutcomesVariability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease
Derbas LA, Patel KK, Muskula PR, Wang J, Gosch K, Fitridge R, Spertus JA, Smolderen KG. Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease. International Journal Of Cardiology 2021, 330: 200-206. PMID: 33581177, DOI: 10.1016/j.ijcard.2021.02.014.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseMedian odds ratioImaging testsSymptomatic peripheral artery diseaseSymptomatic peripheral arterial diseaseInvasive imaging testsPAQ summary scoreVascular specialty clinicsPatient-level factorsPeripheral artery diseaseDiagnostic imaging testsHierarchical logistic regression modelsLogistic regression modelsMean ABIPAD diagnosisNew onsetPAD symptomsPatient demographicsArtery diseasePatient characteristicsVascular clinicArterial diseaseDisease characteristicsRecent exacerbationReferral rates
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