2019
An immunogenic NSCLC microenvironment is associated with favorable survival in lung adenocarcinoma
Givechian KB, Garner C, Benz S, Song B, Rabizadeh S, Soon-Shiong P. An immunogenic NSCLC microenvironment is associated with favorable survival in lung adenocarcinoma. Oncotarget 2019, 10: 1840-1849. PMID: 30956762, PMCID: PMC6442995, DOI: 10.18632/oncotarget.26748.Peer-Reviewed Original ResearchLung squamous cell carcinomaNon-small cell lung cancerSquamous cell carcinomaLung adenocarcinomaTumor microenvironmentCell carcinomaLung cancerFavorable patient survivalImmune-excluded tumorsCell lung cancerInflamed tumor microenvironmentImmune checkpoint marker expressionLung adenocarcinoma subtypesMajor NSCLC subtypesAnti-tumor immunogenicityImmunological mechanismsFavorable survivalPrognostic effectAdenocarcinoma subtypePatient survivalSurvival outcomesNSCLC subtypesImmune cellsNSCLC microenvironmentLUSC samples
2018
Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples
Givechian KB, Wnuk K, Garner C, Benz S, Garban H, Rabizadeh S, Niazi K, Soon-Shiong P. Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples. Npj Genomic Medicine 2018, 3: 14. PMID: 29928512, PMCID: PMC5998068, DOI: 10.1038/s41525-018-0054-7.Peer-Reviewed Original ResearchFavorable clinical featuresTumor microenvironmentTumor samplesGene signatureClinical featuresT cellsImmune gene expression signatureAntitumor activityT cell abundanceCohort of patientsFavorable clinical outcomeRegulatory T cellsAdaptive immune responsesImmunogenic tumor microenvironmentClusters of patientsPatient tumor samplesM1 macrophage subtypeTreg enrichmentTreg studiesImmunogenic tumorsGene expression signaturesOverall survivalClinical outcomesClinical associationsPatient prognosis
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