2021
Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma
Ülgen E, Can Ö, Bilguvar K, Akyerli Boylu C, Kılıçturgay Yüksel Ş, Erşen Danyeli A, Sezerman OU, Yakıcıer MC, Pamir MN, Özduman K. Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma. BMC Medical Genomics 2021, 14: 54. PMID: 33622343, PMCID: PMC7903763, DOI: 10.1186/s12920-021-00904-3.Peer-Reviewed Original ResearchConceptsTumor mutational burdenSomatic copy number alterationsWhole-exome sequencing findingsMicrosatellite instabilityGermline variantsClinical interpretationIndividual brain tumorsShort variantRecurrent tumorsMSI incidenceMutational burdenBrain tumorsLoss of heterozygosityPathway enrichment analysisPrimary gliomasClinical settingTumorsWES analysisCopy number alterationsTumor samplesSequencing findingsDiffuse gliomasClinical analysisGliomasChr10 loss
2020
Mutations and Copy Number Alterations in IDH Wild-Type Glioblastomas Are Shaped by Different Oncogenic Mechanisms
Ülgen E, Karacan S, Gerlevik U, Can Ö, Bilguvar K, Oktay Y, Akyerli C, Yüksel Ş, Danyeli A, Tihan T, Sezerman OU, Yakıcıer MC, Pamir MN, Özduman K. Mutations and Copy Number Alterations in IDH Wild-Type Glioblastomas Are Shaped by Different Oncogenic Mechanisms. Biomedicines 2020, 8: 574. PMID: 33297360, PMCID: PMC7762325, DOI: 10.3390/biomedicines8120574.Peer-Reviewed Original ResearchUnderlying oncogenic mechanismsOncogenic mechanismsNumber alterationsDifferent oncogenic mechanismsDiffuse midline gliomaMismatch repair deficiencySingle nucleotide variationsWhole-exome sequencingIDH wild-type glioblastomaWild-type glioblastomaPrimary tumorMolecular subsetsBlood samplesMidline gliomaAdult diffuse gliomasHeterogenous groupWt glioblastomaCopy number alterationsGliomasRecurrenceExome sequencingDiffuse gliomasRepair deficiencyAlteration frequencyGenomic alterations