Immunotherapy in selected patients with Down syndrome disintegrative disorder
Cardinale KM, Bocharnikov A, Hart SJ, Baker JA, Eckstein C, Jasien JM, Gallentine W, Worley G, Kishnani PS, Van Mater H. Immunotherapy in selected patients with Down syndrome disintegrative disorder. Developmental Medicine & Child Neurology 2018, 61: 847-851. PMID: 30548468, DOI: 10.1111/dmcn.14127.Peer-Reviewed Original ResearchConceptsCognitive declineDisintegrative disorderDown syndromeHistory of autoimmunitySmall case seriesAutoimmune thyroid diseaseSymptoms of catatoniaAdditional immunotherapyIntravenous immunoglobulinCase seriesMedical recordsThyroid diseaseImmunotherapyPAPER ADDSPatientsCatatoniaInsomniaCore symptomsPsychosisAutistic featuresYoung adultsSymptomsAutoimmunityDisordersSyndromeAn Update on the Treatment of Pediatric Autoimmune Encephalitis
Stingl C, Cardinale K, Van Mater H. An Update on the Treatment of Pediatric Autoimmune Encephalitis. Current Treatment Options In Rheumatology 2018, 4: 14-28. PMID: 29780690, PMCID: PMC5957495, DOI: 10.1007/s40674-018-0089-z.Peer-Reviewed Original ResearchSecond-line therapyRefractory diseaseNeuropsychiatric deficitsProspective randomized placebo-controlled trialInterleukin-6 inhibitor tocilizumabLow-dose IL-2Randomized placebo-controlled trialPediatric autoimmune encephalitisPlacebo-controlled trialEarly treatment initiationFirst-line therapyFirst-line treatmentSecond-line agentsIL-6 blockadeMajority of patientsProteasome inhibitorsRecent FindingsTo dateAutoimmune encephalitisTreatment escalationIntravenous immunoglobulinMycophenolate mofetilClinical improvementPharmacologic treatmentPrompt treatmentTreatment initiation
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