Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
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