2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score
2021
Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Constable RT, Chawarska K, Ment LR. Functional Connectivity for the Language Network in the Developing Brain: 30 Weeks of Gestation to 30 Months of Age. Cerebral Cortex 2021, 32: 3289-3301. PMID: 34875024, PMCID: PMC9340393, DOI: 10.1093/cercor/bhab415.Peer-Reviewed Original ResearchConceptsWeeks of gestationFirst postnatal monthMonths of agePostnatal monthFunctional connectivityWernicke's areaWeeks postmenstrual ageLanguage networkResting-state fMRI dataPostmenstrual ageFetal onsetInterhemispheric connectionsIntrahemispheric connectionsPrimary analysisOlder infantsNeurobehavioral disordersSecondary analysisGestationCross-sectional dataMonthsBrocaUnique participantsWeeksSignificant increaseFunctional connectionsAssociations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark
Xiao J, Gao Y, Yu Y, Toft G, Zhang Y, Luo J, Xia Y, Chawarska K, Olsen J, Li J, Liew Z. Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: a population-based multigenerational cohort study in Denmark. International Journal Of Epidemiology 2021, 50: 485-495. PMID: 33411909, PMCID: PMC8128455, DOI: 10.1093/ije/dyaa246.Peer-Reviewed Original ResearchConceptsBirth characteristicsAutism spectrum disorder (ASD) riskCohort studyOdds ratioNationwide register-based cohort studySociodemographic factorsRegister-based cohort studyOffspring of mothersConfidence intervalsASD riskHealth-related factorsExposure risk factorsDisorder riskLogistic regression modelsOffspring of parentsPerinatal factorsPreterm birthFather-child pairsLow birthweightVery pretermEpidemiological evidenceRisk factorsHigh riskElevated riskPaternal factors
2017
The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm
Jensen E, van der Burg J, O'Shea T, Joseph R, Allred E, Heeren T, Leviton A, Kuban K, Investigators E, Shah B, Singh R, Smith A, Klein D, McQuiston S, Rollins J, Douglass L, Ware J, Coster T, Henson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Frazier J, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, O'Shea T, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Burdo-Hartman W, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm. The Journal Of Pediatrics 2017, 187: 50-57.e3. PMID: 28341527, PMCID: PMC5533624, DOI: 10.1016/j.jpeds.2017.02.064.Peer-Reviewed Original ResearchConceptsPrepregnancy body mass indexBody mass indexMaternal prepregnancy body mass indexPregnancy weight gainMass indexNeurocognitive functionWeight gainCohort of infantsMaternal prepregnancy obesityLower scoresYears of ageAge 10 yearsFine motor controlMaternal obesityPrepregnancy weightProspective multicenterCohort studyPrepregnancy obesitySingleton pregnanciesSchool-aged childrenNeurocognitive evaluationStudy participantsBehavioral interventionsTen-year-old childrenExpression assessment
1995
Information processing and developmental assessments in 3-month-old infants exposed prenatally to cocaine.
Mayes LC, Bornstein MH, Chawarska K, Granger RH. Information processing and developmental assessments in 3-month-old infants exposed prenatally to cocaine. Pediatrics 1995, 95: 539-45. PMID: 7700755, DOI: 10.1542/peds.95.4.539.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureInformation processingDevelopmental assessmentEarly cognitive processesInfant information processingInfant-controlled habituationCocaine exposureDrug exposure statusAttention regulationCognitive processesHabituation procedureNovel stimuliBayley MDIHabituation criterionMental ScaleInfant developmentBayley ScalesHabituationDepressed performanceMajority of infantsProcessingMonths of ageExposure statusArousalSociodemographic factors