2025
VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex.
Zhang L, Uygun T, Hahn H, Liu Y, Rivero-RĂos P, Li D, Navratna V, Bristow E, Luo G, Kovarzin A, Bo Y, Gadde S, CĂ´tĂ© M, Ko D, Mosalaganti S, Reinisch K, Weisman L. VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex. Molecular Biology Of The Cell 2025, 36: ar78. PMID: 40305106, DOI: 10.1091/mbc.e24-11-0490.Peer-Reviewed Original ResearchMeSH KeywordsCryoelectron MicroscopyFlavoproteinsHexosyltransferasesHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMutationPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsConceptsPatient mutationsFluorescence-detection size-exclusion chromatographyPI(3,5)P<sub>2</sub>Phosphatidylinositol 3,5-bisphosphatePull-down assaysMedium-resolution structureYeast mutationsPediatric neurodegenerative diseaseVac14Signaling lipidsCell lysatesMutationsOligomerizationNeurodegenerative diseasesElectron microscopy mappingKnockoutFab1/PIKfyveYeastEndosomesFIG4PIKfyveLysatesColocalizationComplexRegulation
2015
The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane
Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nature Cell Biology 2015, 18: 132-138. PMID: 26571211, PMCID: PMC4689616, DOI: 10.1038/ncb3271.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMutationPhosphatidylinositol PhosphatesProtein Structure, TertiaryProtein Transport
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply