2020
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU. C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. Nature Communications 2020, 11: 3354. PMID: 32620797, PMCID: PMC7335171, DOI: 10.1038/s41467-020-17129-0.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinCell Line, TumorCell SurvivalDatasets as TopicDNA Repeat ExpansionEmbryo, MammalianFemaleFrontal LobeFrontotemporal DementiaHumansIntronsMiceNeuronsNonsense Mediated mRNA DecayPrimary Cell CultureProtein BiosynthesisRNA HelicasesRNA-SeqRNA, MessengerTrans-ActivatorsConceptsArginine-rich dipeptide repeatsNonsense-mediated decayRNA surveillanceTranslational repressionNMD inhibitionDipeptide repeatsRNA Decay mechanismsGlobal translational repressionStress granule formationC9ALS/FTDRNA decayFrameshift 1Repeat regionFamilial amyotrophic lateral sclerosisGranule formationCultured cellsFTD brainC9orf72 geneRepressionSurvival of neuronsRepeatsAmyotrophic lateral sclerosisMutantsGenesLateral sclerosis
2013
Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
Guo J, Su Y, Shin J, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming G, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nature Neuroscience 2013, 17: 215-222. PMID: 24362762, PMCID: PMC3970219, DOI: 10.1038/nn.3607.Peer-Reviewed Original ResearchConceptsCpH methylationNon-CpG cytosinesNon-CpG methylationSingle-base resolutionDNA methylome profilingDNA methyltransferase DNMT3ARepress transcriptionCpG dinucleotidesMethyltransferase DNMT3AProtein MeCP2DNANeuronal maturationMethylationMammalian brainDentate gyrus neuronsAdult mammalian brainCpGTranscriptionDinucleotideBisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter
Yeo M, Berglund K, Hanna M, Guo J, Kittur J, Torres M, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke W. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 4315-4320. PMID: 23440186, PMCID: PMC3600491, DOI: 10.1073/pnas.1300959110.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollutants, OccupationalAnimalsBenzhydryl CompoundsCells, CulturedCentral Nervous System DiseasesCerebral CortexChloridesDNA-Binding ProteinsEpigenesis, GeneticFemaleHistone Deacetylase 1HumansK Cl- CotransportersMaleMiceNerve Tissue ProteinsNeuronsPhenolsRatsResponse ElementsSex CharacteristicsSymportersConceptsEffects of bisphenol AKcc2 promoterBisphenol A exposureKCC2 expressionCortical neuronsHistone deacetylase 1Binding of methyl-CpG-binding protein 2Potassium-chloride cotransporter 2KCC2 gene expressionMethyl-CpG-binding protein 2Knockdown of histone deacetylase 1Sexually dimorphic mannerSexually dimorphic effectsHuman neurodevelopmental disordersBisphenol-A effectsHuman cortical neuronsToxic mechanisms of bisphenol ANeuronal chlorideCotransporter 2Cortical slicesBinding protein 2KCC2Mouse damsDimorphic mannerInterneuron migration
2012
Neuronal activation and insight into the plasticity of DNA methylation
Felling R, Guo J, Song H. Neuronal activation and insight into the plasticity of DNA methylation. Epigenomics 2012, 4: 125-127. PMID: 22449183, DOI: 10.2217/epi.12.2.Peer-Reviewed Original Research
2011
Neuronal activity modifies the DNA methylation landscape in the adult brain
Guo J, Ma D, Mo H, Ball M, Jang M, Bonaguidi M, Balazer J, Eaves H, Xie B, Ford E, Zhang K, Ming G, Gao Y, Song H. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nature Neuroscience 2011, 14: 1345-1351. PMID: 21874013, PMCID: PMC3183401, DOI: 10.1038/nn.2900.Peer-Reviewed Original Research
2010
Epigenetic choreographers of neurogenesis in the adult mammalian brain
Ma D, Marchetto M, Guo J, Ming G, Gage F, Song H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nature Neuroscience 2010, 13: 1338-1344. PMID: 20975758, PMCID: PMC3324277, DOI: 10.1038/nn.2672.Peer-Reviewed Original Research
2009
DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
Kim J, Duan X, Liu C, Jang M, Guo J, Pow-anpongkul N, Kang E, Song H, Ming G. DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212. Neuron 2009, 63: 761-773. PMID: 19778506, PMCID: PMC3075620, DOI: 10.1016/j.neuron.2009.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnalysis of VarianceAnimalsAnimals, NewbornCell MovementCells, CulturedFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGreen Fluorescent ProteinsHippocampusHumansImmunoprecipitationImmunosuppressive AgentsMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuronsOncogene Protein v-aktPregnancyProtein BindingRNA InterferenceSignal TransductionSirolimusTransfectionConceptsDisrupted-in-schizophrenia 1Susceptibility genesMammalian target of rapamycinNeuronal developmentAkt-binding partnersAkt downstream effectorsAkt signalingRegulate multiple aspectsAkt activation in vitroDisrupted-in-schizophreniaMultiple susceptibility genesPharmacological inhibition of mammalian target of rapamycinSchizophrenia susceptibility genesRegulate neuronal developmentSignaling of AktNeurons in vivoAkt-mTOR signaling pathwayInhibition of mammalian target of rapamycinBinding partnersAkt-mTOR signalingDownstream effectorsGenetic manipulationTarget of rapamycinActivity in vitroNewborn neurons
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