2020
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU. C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. Nature Communications 2020, 11: 3354. PMID: 32620797, PMCID: PMC7335171, DOI: 10.1038/s41467-020-17129-0.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinCell Line, TumorCell SurvivalDatasets as TopicDNA Repeat ExpansionEmbryo, MammalianFemaleFrontal LobeFrontotemporal DementiaHumansIntronsMiceNeuronsNonsense Mediated mRNA DecayPrimary Cell CultureProtein BiosynthesisRNA HelicasesRNA-SeqRNA, MessengerTrans-ActivatorsConceptsArginine-rich dipeptide repeatsNonsense-mediated decayRNA surveillanceTranslational repressionNMD inhibitionDipeptide repeatsRNA Decay mechanismsGlobal translational repressionStress granule formationC9ALS/FTDRNA decayFrameshift 1Repeat regionFamilial amyotrophic lateral sclerosisGranule formationCultured cellsFTD brainC9orf72 geneRepressionSurvival of neuronsRepeatsAmyotrophic lateral sclerosisMutantsGenesLateral sclerosis
2013
Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter
Yeo M, Berglund K, Hanna M, Guo J, Kittur J, Torres M, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke W. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 4315-4320. PMID: 23440186, PMCID: PMC3600491, DOI: 10.1073/pnas.1300959110.Peer-Reviewed Original ResearchMeSH KeywordsAir Pollutants, OccupationalAnimalsBenzhydryl CompoundsCells, CulturedCentral Nervous System DiseasesCerebral CortexChloridesDNA-Binding ProteinsEpigenesis, GeneticFemaleHistone Deacetylase 1HumansK Cl- CotransportersMaleMiceNerve Tissue ProteinsNeuronsPhenolsRatsResponse ElementsSex CharacteristicsSymportersConceptsEffects of bisphenol AKcc2 promoterBisphenol A exposureKCC2 expressionCortical neuronsHistone deacetylase 1Binding of methyl-CpG-binding protein 2Potassium-chloride cotransporter 2KCC2 gene expressionMethyl-CpG-binding protein 2Knockdown of histone deacetylase 1Sexually dimorphic mannerSexually dimorphic effectsHuman neurodevelopmental disordersBisphenol-A effectsHuman cortical neuronsToxic mechanisms of bisphenol ANeuronal chlorideCotransporter 2Cortical slicesBinding protein 2KCC2Mouse damsDimorphic mannerInterneuron migrationSecreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis
Jang M, Bonaguidi M, Kitabatake Y, Sun J, Song J, Kang E, Jun H, Zhong C, Su Y, Guo J, Wang M, Sailor K, Kim J, Gao Y, Christian K, Ming G, Song H. Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis. Cell Stem Cell 2013, 12: 215-223. PMID: 23395446, PMCID: PMC3569732, DOI: 10.1016/j.stem.2012.11.021.Peer-Reviewed Original ResearchConceptsNeural stem cellsAdult neurogenesisGranule neuronsStem cellsMature dentate granule neuronsDentate gyrus granule neuronsActivity-dependent regulationActivity-dependent mechanismsAdult mouse hippocampusDentate granule neuronsNeuronal circuit activityRegulates multiple phasesRadial neural stem cellsAdult neural stem cellsAdult hippocampal neurogenesisSecreted Wnt inhibitorNeural progenitor proliferationTonic inhibitionDendritic spine formationAcute releaseMature neuronsNeuronal maturationProgenitor proliferationWnt inhibitorsNeuronal activity
2011
Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
Kang E, Burdick K, Kim J, Duan X, Guo J, Sailor K, Jung D, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra A, Song H, Ming G. Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia. Neuron 2011, 72: 559-571. PMID: 22099459, PMCID: PMC3222865, DOI: 10.1016/j.neuron.2011.09.032.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAnimalsCase-Control StudiesCells, CulturedFemaleGene Knockdown TechniquesGenetic Association StudiesHippocampusHumansMaleMiceMice, Inbred C57BLMiddle AgedNerve Tissue ProteinsNeurogenesisPolymorphism, Single NucleotideProtein BindingRisk FactorsSchizophreniaConceptsDisrupted-in-schizophrenia 1Neuronal developmentElongation protein zeta-1Genetic association analysisRegulate cell positioningRegulation of neuronal developmentDendritic growth of newborn neuronsNewborn neuronsEpistatic interactionsScaffold proteinAssociation analysisSchizophrenia 1Susceptibility genesIntracellular partnersCohort of schizophrenia patientsFEZ1Adult mouse hippocampusRisk of schizophreniaZeta 1Schizophrenia patientsHealthy controlsCell positionIncreased riskMouse hippocampusMental disorders
2009
DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
Kim J, Duan X, Liu C, Jang M, Guo J, Pow-anpongkul N, Kang E, Song H, Ming G. DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212. Neuron 2009, 63: 761-773. PMID: 19778506, PMCID: PMC3075620, DOI: 10.1016/j.neuron.2009.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnalysis of VarianceAnimalsAnimals, NewbornCell MovementCells, CulturedFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGreen Fluorescent ProteinsHippocampusHumansImmunoprecipitationImmunosuppressive AgentsMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuronsOncogene Protein v-aktPregnancyProtein BindingRNA InterferenceSignal TransductionSirolimusTransfectionConceptsDisrupted-in-schizophrenia 1Susceptibility genesMammalian target of rapamycinNeuronal developmentAkt-binding partnersAkt downstream effectorsAkt signalingRegulate multiple aspectsAkt activation in vitroDisrupted-in-schizophreniaMultiple susceptibility genesPharmacological inhibition of mammalian target of rapamycinSchizophrenia susceptibility genesRegulate neuronal developmentSignaling of AktNeurons in vivoAkt-mTOR signaling pathwayInhibition of mammalian target of rapamycinBinding partnersAkt-mTOR signalingDownstream effectorsGenetic manipulationTarget of rapamycinActivity in vitroNewborn neurons
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