2023
Stress promotes RNA G-quadruplex folding in human cells
Kharel P, Fay M, Manasova E, Anderson P, Kurkin A, Guo J, Ivanov P. Stress promotes RNA G-quadruplex folding in human cells. Nature Communications 2023, 14: 205. PMID: 36639366, PMCID: PMC9839774, DOI: 10.1038/s41467-023-35811-x.Peer-Reviewed Original ResearchConceptsHuman cellsMRNA stabilityCellular stress responseRG4 structuresG-quadruplex structuresRNA G4sDynamic regulationG-quadruplex foldingRich nucleic acidsStress responsePermissive conditionsRG4FoldingStress removalRegulatory impactNucleic acidsCellsDimethylsulfateRNAMotifGuanineMRNARegulationStressSequence
2016
RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria
Guo J, Bartel D. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Science 2016, 353: aaf5371-aaf5371. PMID: 27708011, PMCID: PMC5367264, DOI: 10.1126/science.aaf5371.Peer-Reviewed Original ResearchConceptsRNA G-quadruplexesEukaryotic cellsG-quadruplexStable four-stranded structuresG-quadruplexes in vitroG-quadruplex-forming sequencesPosttranscriptional gene regulationG-quadruplex-forming regionsFour-stranded structuresBacterial transcriptomesRNA regionsGene regulationEscherichia coliImpaired translationRNABacteriaCellsIn vitroEukaryotesTranscriptomeSequenceMachineryRegionRegulation
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