2021
Regulation of nonsense-mediated mRNA decay in neural development and disease
Lee PJ, Yang S, Sun Y, Guo JU. Regulation of nonsense-mediated mRNA decay in neural development and disease. Journal Of Molecular Cell Biology 2021, 13: 269-281. PMID: 33783512, PMCID: PMC8339359, DOI: 10.1093/jmcb/mjab022.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsCentral Nervous SystemCodon, NonsenseGene Expression Regulation, DevelopmentalHumansMutationNeurodevelopmental DisordersNonsense Mediated mRNA DecayProtein BiosynthesisRNA, MessengerConceptsAberrant mRNAsNonsense-mediated mRNA decayMRNA decay functionCore NMD factorsMRNA surveillance mechanismGene regulation mechanismsQuality control mechanismsPremature termination codonNMD factorsPhysiological mRNAsOrganismal levelMRNA decayDevelopmental regulationGenetic evidenceMolecular basisTermination codonBiological functionsRegulation mechanismNeural developmentPhysiological functionsSurveillance mechanismNMDNeurodegenerative diseasesMRNACritical role
2015
A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation
Sun J, Bonaguidi M, Jun H, Guo J, Sun G, Will B, Yang Z, Jang M, Song H, Ming G, Christian K. A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation. Molecular Brain 2015, 8: 52. PMID: 26337530, PMCID: PMC4559945, DOI: 10.1186/s13041-015-0143-9.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornDentate GyrusGene Expression Regulation, DevelopmentalGlycoproteinsIntracellular Signaling Peptides and ProteinsMice, Inbred C57BLMice, KnockoutNeural Stem CellsNeurogenesisNeurogliaRNA, MessengerTime FactorsConceptsRadial glia-like neural stem cellsSepto-temporal axisAdult dentate gyrusDentate gyrusAdult hippocampal neurogenesisMouse dentate gyrusAdult mouse dentate gyrusHippocampal neurogenesisStem cell activityLevels of adult hippocampal neurogenesisIn situ hybridizationMechanisms regulating proliferationNeural stem cell activityQuantitative real-time PCRNeural stem cellsMCM2 expressionReal-time PCRCell activationMature neuronsPostnatal developmentSFRP3Stem cellsMolecular mechanismsProtein 3Suppressive activity
2009
DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
Kim J, Duan X, Liu C, Jang M, Guo J, Pow-anpongkul N, Kang E, Song H, Ming G. DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212. Neuron 2009, 63: 761-773. PMID: 19778506, PMCID: PMC3075620, DOI: 10.1016/j.neuron.2009.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnalysis of VarianceAnimalsAnimals, NewbornCell MovementCells, CulturedFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGreen Fluorescent ProteinsHippocampusHumansImmunoprecipitationImmunosuppressive AgentsMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuronsOncogene Protein v-aktPregnancyProtein BindingRNA InterferenceSignal TransductionSirolimusTransfectionConceptsDisrupted-in-schizophrenia 1Susceptibility genesMammalian target of rapamycinNeuronal developmentAkt-binding partnersAkt downstream effectorsAkt signalingRegulate multiple aspectsAkt activation in vitroDisrupted-in-schizophreniaMultiple susceptibility genesPharmacological inhibition of mammalian target of rapamycinSchizophrenia susceptibility genesRegulate neuronal developmentSignaling of AktNeurons in vivoAkt-mTOR signaling pathwayInhibition of mammalian target of rapamycinBinding partnersAkt-mTOR signalingDownstream effectorsGenetic manipulationTarget of rapamycinActivity in vitroNewborn neurons
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