Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression
Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo J, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming G, Jin P, Song H. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell 2015, 61: 153-160. PMID: 26711009, PMCID: PMC4779955, DOI: 10.1016/j.molcel.2015.11.020.Peer-Reviewed Original ResearchConceptsFunctions of Lin28ADNA sequences in vitroLet-7 miRNA biogenesisGenomic binding sitesTranscription start siteEmbryonic stem cells in vivoRNA-binding proteinsSequences in vitroRegulate gene expressionEpigenetic DNA modificationMRNA translation efficiencyDysregulated DNA methylationChIP-seqGenomic occupancyStart siteRNA-seqTranscriptional regulationTranslational efficiencyDNA methylationMiRNA biogenesisDNA modificationsMammalian systemsTarget genesTET1 knockdownGene expression
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