2020
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU. C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. Nature Communications 2020, 11: 3354. PMID: 32620797, PMCID: PMC7335171, DOI: 10.1038/s41467-020-17129-0.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinCell Line, TumorCell SurvivalDatasets as TopicDNA Repeat ExpansionEmbryo, MammalianFemaleFrontal LobeFrontotemporal DementiaHumansIntronsMiceNeuronsNonsense Mediated mRNA DecayPrimary Cell CultureProtein BiosynthesisRNA HelicasesRNA-SeqRNA, MessengerTrans-ActivatorsConceptsArginine-rich dipeptide repeatsNonsense-mediated decayRNA surveillanceTranslational repressionNMD inhibitionDipeptide repeatsRNA Decay mechanismsGlobal translational repressionStress granule formationC9ALS/FTDRNA decayFrameshift 1Repeat regionFamilial amyotrophic lateral sclerosisGranule formationCultured cellsFTD brainC9orf72 geneRepressionSurvival of neuronsRepeatsAmyotrophic lateral sclerosisMutantsGenesLateral sclerosis
2014
Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain
Guo J, Szulwach K, Su Y, Li Y, Yao B, Xu Z, Shin J, Xie B, Gao Y, Ming G, Jin P, Song H. Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain. Frontiers In Biology 2014, 9: 66-74. PMID: 25568643, PMCID: PMC4284063, DOI: 10.1007/s11515-014-1295-1.Peer-Reviewed Original ResearchActive DNA demethylationDNA methylomeDNA demethylationDNA methylationGenome-wide distribution of 5hmCGenome-wide distributionGenome-wide comparisonDistribution of 5hmCGranule neurons in vivoGene expression profilesGene bodiesCytosine modificationsNeuronal genomeMammalian nervous systemDNA modificationsGene expressionEmbryonic stem cellsDNAAdult mouse brainFunctional disparityGenesMethylomeCell typesIntegrated analysisGranule neurons
2010
Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain
Ma D, Guo J, Ming G, Song H. Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain. Research And Perspectives In Alzheimer's Disease 2010, 113-123. DOI: 10.1007/978-3-642-16602-0_10.Peer-Reviewed Original ResearchEpigenetic modificationsDNA methylationDNA methylation landscapeStable epigenetic markerMechanisms of neural plasticityLearning-related stimuliDemethylation machineryMethylation landscapeNeuronal genomeEpigenetic markersGene expressionPsychiatric disordersDNAActivity-dependent inductionNeural plasticityExternal cuesNeuronal activityPotential therapeutic interventionsGenesSensory informationAdult brainSensory experienceBrainGenomeNeuronal properties
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