2021
Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting
Sun Y, Abriola L, Niederer RO, Pedersen SF, Alfajaro MM, Silva Monteiro V, Wilen CB, Ho YC, Gilbert WV, Surovtseva YV, Lindenbach BD, Guo JU. Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2023051118. PMID: 34185680, PMCID: PMC8256030, DOI: 10.1073/pnas.2023051118.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 replicationSARS-CoV-2Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Vero E6 cellsHigh-throughput compound screenOpen reading frame 1bEffective antiviral strategiesCoronavirus 2E6 cellsAntiviral strategiesViral gene expressionCompound screenFluoroquinolone antibacterialsFrame 1bGene expression
2015
Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression
Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo J, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming G, Jin P, Song H. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell 2015, 61: 153-160. PMID: 26711009, PMCID: PMC4779955, DOI: 10.1016/j.molcel.2015.11.020.Peer-Reviewed Original ResearchConceptsFunctions of Lin28ADNA sequences in vitroLet-7 miRNA biogenesisGenomic binding sitesTranscription start siteEmbryonic stem cells in vivoRNA-binding proteinsSequences in vitroRegulate gene expressionEpigenetic DNA modificationMRNA translation efficiencyDysregulated DNA methylationChIP-seqGenomic occupancyStart siteRNA-seqTranscriptional regulationTranslational efficiencyDNA methylationMiRNA biogenesisDNA modificationsMammalian systemsTarget genesTET1 knockdownGene expression
2014
Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain
Guo J, Szulwach K, Su Y, Li Y, Yao B, Xu Z, Shin J, Xie B, Gao Y, Ming G, Jin P, Song H. Genome-wide antagonism between 5-hydroxymethylcytosine and DNA methylation in the adult mouse brain. Frontiers In Biology 2014, 9: 66-74. PMID: 25568643, PMCID: PMC4284063, DOI: 10.1007/s11515-014-1295-1.Peer-Reviewed Original ResearchActive DNA demethylationDNA methylomeDNA demethylationDNA methylationGenome-wide distribution of 5hmCGenome-wide distributionGenome-wide comparisonDistribution of 5hmCGranule neurons in vivoGene expression profilesGene bodiesCytosine modificationsNeuronal genomeMammalian nervous systemDNA modificationsGene expressionEmbryonic stem cellsDNAAdult mouse brainFunctional disparityGenesMethylomeCell typesIntegrated analysisGranule neuronsExpanded identification and characterization of mammalian circular RNAs
Guo J, Agarwal V, Guo H, Bartel D. Expanded identification and characterization of mammalian circular RNAs. Genome Biology 2014, 15: 409. PMID: 25070500, PMCID: PMC4165365, DOI: 10.1186/s13059-014-0409-z.Peer-Reviewed Original ResearchConceptsRNA-seq dataRNA-seqHuman circRNAsProtein-coding sequencesZinc-finger proteinProperties of circRNAsRegulate gene expressionCell type-specificCircular RNAsSequence conservationENCODE projectRibosome profilingMiRNA sitesTopological isoformsComputational pipelineBiological functionsMouse circRNAsGene expressionMiR-7 spongeLow abundanceCell typesExpression levelsRNACircRNAsSequence
2011
Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
Guo J, Su Y, Zhong C, Ming G, Song H. Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain. Cell 2011, 145: 423-434. PMID: 21496894, PMCID: PMC3088758, DOI: 10.1016/j.cell.2011.03.022.Peer-Reviewed Original ResearchConceptsActive DNA demethylationDNA demethylationMammalian cellsHydroxylation of 5-methylcytosineMammalian genomic DNABase excision repair pathwayPromoter DNA demethylationHuman DNA glycosylasesExcision repair pathwayAdult mouse brain in vivoCytosine methylationEpigenetic marksTranscriptional regulationGenomic DNADNA glycosylaseRepair pathwaysCovalent modificationGene expressionMolecular mechanismsActivity-inducedCytidine deaminaseEnzymatic removalDemethylationTET1Mouse brain in vivo
2010
Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain
Ma D, Guo J, Ming G, Song H. Bridging Environment and DNA: Activity-Induced Epigenetic Modification in the Adult Brain. Research And Perspectives In Alzheimer's Disease 2010, 113-123. DOI: 10.1007/978-3-642-16602-0_10.Peer-Reviewed Original ResearchEpigenetic modificationsDNA methylationDNA methylation landscapeStable epigenetic markerMechanisms of neural plasticityLearning-related stimuliDemethylation machineryMethylation landscapeNeuronal genomeEpigenetic markersGene expressionPsychiatric disordersDNAActivity-dependent inductionNeural plasticityExternal cuesNeuronal activityPotential therapeutic interventionsGenesSensory informationAdult brainSensory experienceBrainGenomeNeuronal properties
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